WWP2 and SNRPC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		WWP2	SNRPC
Description		WW domain containing E3 ubiquitin protein ligase 2	small nuclear ribonucleoprotein polypeptide C
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Commitment Complex Nucleoplasm U1 SnRNP Cajal Body U2-type Prespliceosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity U1 SnRNP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome
Pathways		Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglycerides ( 30275531)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol ( 25961943) Obese vs. thin ( 30677029) Systemic lupus erythematosus ( 24871463)
Interacting Genes		60 interacting genes: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 GRAP2 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 NUTF2 PAIP1 PDLIM7 PSMF1 PTEN RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SMAD3 SMAD7 SNRPC SPART TFAP2A TNK2 TP53BP2 TP73 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1 ZNF688	28 interacting genes: AGGF1 DDX42 EWSR1 EXOSC8 FAM168A GOLGA2 HNRNPD HNRNPF HNRNPH2 HNRNPUL1 HSD17B14 ILF3 KHDRBS3 MAGED1 NCAPH2 PSMA3 RBFOX2 RBM11 RBM4 RBPMS RFX6 RNF31 SNRNP70 SPAG8 SS18L1 TLE5 WDR77 WWP2
Entrez ID		11060	6631
HPRD ID		03812	04630
Ensembl ID		ENSG00000198373	ENSG00000124562
Uniprot IDs		A0A024R711 B4DHF6 O00308	P09234 Q5TAL4
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS	2VRD 3CW1 4PJO 6ELD 6QX9
Enriched GO Terms of Interacting Partners?
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