WWP2 and SPART

Number of citations of the paper that reports this interaction (PubMedID 19307600)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		WWP2	SPART
Description		WW domain containing E3 ubiquitin protein ligase 2	spartin
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development
Pathways		Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglycerides ( 30275531)
Interacting Genes		60 interacting genes: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 GRAP2 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 NUTF2 PAIP1 PDLIM7 PSMF1 PTEN RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SMAD3 SMAD7 SNRPC SPART TFAP2A TNK2 TP53BP2 TP73 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1 ZNF688	11 interacting genes: APP EPS15 ITCH MAP3K1 PLIN3 POSTN SMURF1 SMURF2 TUBA1A WWP2 ZFYVE9
Entrez ID		11060	23111
HPRD ID		03812	06170
Ensembl ID		ENSG00000198373	ENSG00000133104
Uniprot IDs		A0A024R711 B4DHF6 O00308	A0A024RDV9 Q8N0X7
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS	2DL1 4U7I
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?