YWHAQ and CDC25C

Number of citations of the paper that reports this interaction (PubMedID 15629715)
141

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		YWHAQ	CDC25C
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	cell division cycle 25C
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Protein N-terminus Binding 14-3-3 Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding
	Biological Process	Protein Targeting Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transcription, DNA-templated Membrane Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Nuclear Division Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)
Interacting Genes		235 interacting genes: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ARHGEF2 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRAF6 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBE2L3 UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	35 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 ERBB3 ERBB4 FHL1 HRAS LCK LMTK2 LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ
Entrez ID		10971	995
HPRD ID		00886	01146
Ensembl ID		ENSG00000134308	ENSG00000158402
Uniprot IDs		P27348	B4DX61 P30307
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT	2OJX 3BZI 3OP3 5M35 5M36 5M37
Enriched GO Terms of Interacting Partners?
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