CDC25C and MARK3

Number of citations of the paper that reports this interaction (PubMedID 9278512)
353

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CDC25C	MARK3
Description		cell division cycle 25C	microtubule affinity regulating kinase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Nuclear Division Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation
Pathways		Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)	Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Coronary artery disease ( 29212778) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Monocyte count ( 29403010 27863252) Optic disc size ( 31809533) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969)
Interacting Genes		35 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 ERBB3 ERBB4 FHL1 HRAS LCK LMTK2 LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ	35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		995	4140
HPRD ID		01146	04058
Ensembl ID		ENSG00000158402	ENSG00000075413
Uniprot IDs		B4DX61 P30307	P27448 Q86U11
PDB IDs		2OJX 3BZI 3OP3 5M35 5M36 5M37	2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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