CCL27 and ACKR2

Number of citations of the paper that reports this interaction (PubMedID 11821900)
150

Data Source:
HPRD (in vivo)

		CCL27	ACKR2
Description		C-C motif chemokine ligand 27	atypical chemokine receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cell Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Actin Cytoskeleton Reorganization	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 29875488 28240269) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		2 interacting genes: ACKR2 CCR10	18 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 GPX1 RHOA
Entrez ID		10850	1238
HPRD ID		05321	09095
Ensembl ID		ENSG00000213927	ENSG00000144648
Uniprot IDs		Q5VZ77 Q9Y4X3	A1LP82 O00590
PDB IDs		2KUM
Enriched GO Terms of Interacting Partners?
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