ACKR2 and CCL25

Number of citations of the paper that reports this interaction (PubMedID 10706668)
34

Data Source:
HPRD (in vivo)

		ACKR2	CCL25
Description		atypical chemokine receptor 2	C-C motif chemokine ligand 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Hormone Activity Protein Binding Chemokine Activity CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Leukocyte Tethering Or Rolling
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Sphingolipid levels ( 26068415)
Interacting Genes		18 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 GPX1 RHOA	4 interacting genes: ACKR2 ACKR4 CCR10 CCR9
Entrez ID		1238	6370
HPRD ID		09095	03976
Ensembl ID		ENSG00000144648	ENSG00000131142
Uniprot IDs		A1LP82 O00590	O15444
PDB IDs
Enriched GO Terms of Interacting Partners?
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