CFTR and CLCN3

Number of citations of the paper that reports this interaction (PubMedID 12471024)
39

Data Source:
BioGRID (pull down)

		CFTR	CLCN3
Description		CF transmembrane conductance regulator	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane	Golgi Membrane Cell Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Intracellular Membrane-bounded Organelle Phagocytic Vesicle
	Molecular Function	Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATPase Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Chaperone Binding Sec61 Translocon Complex Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Solute:proton Antiporter Activity PDZ Domain Binding Chloride Ion Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Cholesterol Biosynthetic Process Vesicle Docking Involved In Exocytosis Bicarbonate Transport Protein Deubiquitination Cholesterol Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal Water Homeostasis Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Membrane Organization Cellular Response To CAMP Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin	Regulation Of PH Negative Regulation Of Cell Volume Endosomal Lumen Acidification Chloride Transmembrane Transport Proton Transmembrane Transport
Pathways		ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Stimuli-sensing channels
Drugs		ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor
Diseases		Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		29 interacting genes: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 MARCHF2 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STUB1 STX1A UBE2I	6 interacting genes: CFTR DNAJC5 GOPC HSPB1 PDZK1 SLC9A3R1
Entrez ID		1080	1182
HPRD ID		03883	02785
Ensembl ID		ENSG00000001626	ENSG00000109572
Uniprot IDs		A0A024R730 P13569	B3KXK0 P51790
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6HEP 6MSM 6O1V 6O2P
Enriched GO Terms of Interacting Partners?
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