MAP3K2 and PIBF1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		MAP3K2	PIBF1
Description		mitogen-activated protein kinase kinase kinase 2	progesterone immunomodulatory binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Extracellular Space Cell Nucleus Cytoplasm Centrosome Centriolar Satellite
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Interleukin-4 Receptor Binding Protein Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Immune System Process Mitotic Metaphase Plate Congression Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Cilium Assembly Protein Localization To Centrosome Mitotic Spindle Assembly Non-motile Cilium Assembly
Pathways
Drugs		Bosutinib
Diseases
GWAS		Protein C levels ( 28082259)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood pressure measurement (low sodium intervention) ( 24165912) Mean corpuscular hemoglobin ( 27863252) Waist circumference ( 28552196)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	5 interacting genes: APP CEP135 CEP70 HAUS1 MAP3K2
Entrez ID		10746	10464
HPRD ID		10068	06337
Ensembl ID		ENSG00000169967	ENSG00000083535
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q8WXW3
PDB IDs		2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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