OGA and C6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		OGA	C6
Description		O-GlcNAcase	complement C6
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GO Annotations	Cellular Component	Nucleus Cytosol Membrane	Extracellular Region Membrane Attack Complex Extracellular Exosome
	Molecular Function	Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity	Protein Binding
	Biological Process	N-acetylglucosamine Metabolic Process Protein O-linked Glycosylation Glycoprotein Catabolic Process Protein Deglycosylation Glycoprotein Metabolic Process Viral Process	In Utero Embryonic Development Positive Regulation Of Activation Of Membrane Attack Complex Complement Activation Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Angiogenesis
Pathways			Terminal pathway of complement Regulation of Complement cascade
Drugs		Streptozocin
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS			Blood protein levels ( 28240269) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		10 interacting genes: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32	4 interacting genes: C5 F2 OGA SART3
Entrez ID		10724	729
HPRD ID		04949	01956
Ensembl ID		ENSG00000198408	ENSG00000039537
Uniprot IDs		O60502	P13671
PDB IDs		2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX 6HKI 6PM9	3T5O 4A5W 4E0S 6H03 6H04
Enriched GO Terms of Interacting Partners?
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