SH2B2 and PDLIM7

Number of citations of the paper that reports this interaction (PubMedID 15946664)
11

Data Source:
HPRD (in vivo, two hybrid)

		SH2B2	PDLIM7
Description		SH2B adaptor protein 2	PDZ and LIM domain 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	RET signaling
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		10603	9260
HPRD ID		16097	10436
Ensembl ID		ENSG00000160999	ENSG00000196923
Uniprot IDs		O14492	Q9NR12
PDB IDs		1Q2H	2Q3G
Enriched GO Terms of Interacting Partners?
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