ARFGEF2 and GABRB1

Number of citations of the paper that reports this interaction (PubMedID 15198677)
44

Data Source:
HPRD (two hybrid)

		ARFGEF2	GABRB1
Description		ADP ribosylation factor guanine nucleotide exchange factor 2	gamma-aminobutyric acid type A receptor subunit beta1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome	Nuclear Envelope Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	GABA-A Receptor Activity Ligand-gated Ion Channel Activity GABA-gated Chloride Ion Channel Activity GABA Receptor Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction	Ion Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Response To Toxic Substance Central Nervous System Neuron Development Response To Progesterone Ion Transmembrane Transport Regulation Of Membrane Potential Ovulation Cycle Nervous System Process Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport
Pathways		Association of TriC/CCT with target proteins during biosynthesis	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Glutethimide Gamma Hydroxybutyric Acid Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Stiripentol Thiocolchicoside
Diseases		Periventricular nodular heterotopia (PVNH)
GWAS		Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)	Adventurousness ( 30643258) Cervical cancer ( 28806749) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Major depressive disorder ( 29317602) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		9 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A	7 interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA UBQLN1
Entrez ID		10564	2560
HPRD ID		09250	15924
Ensembl ID		ENSG00000124198	ENSG00000163288
Uniprot IDs		Q59FR3 Q86TH5 Q9Y6D5	P18505 X5DNL6
PDB IDs		3L8N 3SWV
Enriched GO Terms of Interacting Partners?
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