KAT5 and AR

Number of citations of the paper that reports this interaction (PubMedID 11994312)
95

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		KAT5	AR
Description		lysine acetyltransferase 5	androgen receptor
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nuclear Chromatin Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Acetyltransferase Activity Histone Binding Metal Ion Binding Androgen Receptor Binding Peptide-lysine-N-acetyltransferase Activity Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Basal Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Androgen Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Transcription Regulatory Region DNA Binding ATPase Binding POU Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Positive Regulation Of Autophagy Viral Process Histone Acetylation Peptidyl-lysine Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Acetylation Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Systemic Arterial Blood Pressure Epithelial Cell Morphogenesis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Spermatogenesis Single Fertilization Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Protein Deubiquitination Male Somatic Sex Determination Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Leydig Cell Differentiation Multicellular Organism Growth Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Developmental Growth Animal Organ Formation Male Genitalia Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Prostate Induction By Androgen Receptor Signaling Pathway Morphogenesis Of An Epithelial Fold Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Testosterone Stimulus Seminiferous Tubule Development Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation
Drugs		Coenzyme A S-Acetyl-Cysteine	Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Flutamide Oxandrolone Fluphenazine Testosterone Mitotane Estrone Nilutamide Tamoxifen Fludrocortisone Drostanolone Norgestimate Nandrolone phenpropionate Ketoconazole Acetophenazine Bicalutamide Fluoxymesterone Drospirenone Danazol Testosterone Propionate Oxybenzone Delta1-dihydrotestosterone Boldenone Calusterone Propericiazine Prasterone Flufenamic Acid Dihydrotestosterone (R)-Bicalutamide Methyltrienolone (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Cyproterone acetate LGD2941 Oxymetholone Methyltestosterone Norelgestromin 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL Triclosan Nandrolone decanoate Ulipristal Enzalutamide Eugenol Dienogest Norgestrel Homosalate Enzacamene Esculin
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism Prostate cancer Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglycerides ( 30275531)	Balding ( 26926045) Excessive daytime sleepiness ( 27992416) LDL cholesterol ( 19060910) Male-pattern baldness ( 29146897 22693459 27182965 22032556 18849991 28196072) Prostate cancer ( 21743467)
Interacting Genes		144 interacting genes: AGO2 ALOX12 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DNAAF6 DUSP23 E2F1 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL2 GOLGA2 GSTO1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 IK IKZF3 IL9R KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PFKP PHC2 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SRSF2 SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YIF1A YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513	219 interacting genes: ACTB AHR AKT1 APOL2 APPBP2 ARID5A ATF2 BAG1 BRCA1 CACUL1 CALM1 CALR CASP1 CASP3 CASP7 CASP8 CAV1 CCAR2 CCND1 CCNE1 CCNH CDC25A CDC25B CDC37 CDK1 CDK6 CDK7 CDK9 CEBPA CEBPB CHD8 COX5B CREBBP CTDSP2 CTNNB1 CUL4B DAP3 DAXX DCAF6 DCC DDB2 DDC DENND5A EFCAB6 EGFR ELF3 EP300 ERCC2 ERCC3 ESR1 ETV5 FHL2 FLNA FOXA1 FOXG1 FOXO1 GADD45GIP1 GAK GAPDH GLI2 GRIP1 GSK3B GSN GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 HDAC1 HDAC3 HDAC4 HIF1A HIPK3 HMGB1 HMGB2 HOTAIR HSP90AA1 IARS1 IDE IFI16 IL6ST JMJD1C JUN KAT2B KAT5 KAT7 KDM1A KIF1A KIFAP3 KLK2 LCOR MAGEA11 MAPK1 MDM2 MDN1 MED1 MED12L MED14 MED24 MLH3 MYBBP1A MYLIP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NDE1 NELFCD NFKB1 NISCH NLRP10 NONO NR0B1 NR0B2 NR2C1 NR2C2 NR3C1 NR3C2 NR5A1 NRIP1 NSD1 NSD2 PA2G4 PAK6 PELP1 PIAS1 PIAS2 PIAS3 PIAS4 PNRC1 PNRC2 POU2F1 POU2F2 POU5F1 PRKG1 PRMT1 PRPF6 PSMC3IP PTEN PXN RAC3 RACK1 RAD54L2 RAD9A RAF1 RAN RANBP9 RB1 RBAK RCHY1 REL RELA REPS2 RNASEL RNF14 RNF4 RNF6 RUNX1 RUNX2 SART3 SFPQ SH3YL1 SIRT1 SLC25A4 SMAD1 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCE1 SP1 SPDEF SPOP SRC SREBF1 SRY STAT3 STUB1 SUMO1 SUV39H2 SVIL TADA3 TAF1 TBP TCF20 TCF4 TCF7L2 TDG TGFB1I1 TGIF1 TLE5 TMF1 TNK2 TPD52 TRIM24 TRIP4 TSG101 TXNDC5 UBE2I UBE3A USP10 UXT VCP VHL WIPI1 XRCC5 XRCC6 YWHAQ ZBTB1 ZBTB16 ZBTB32 ZBTB7A ZMIZ1 ZMIZ2 ZNF451
Entrez ID		10524	367
HPRD ID		03245	02437
Ensembl ID		ENSG00000172977	ENSG00000169083
Uniprot IDs		A0A024R597 A0A024R5E8 Q92993	A0A087WUX9 F1D8N5 G4VV16 P10275 Q9NUA2
PDB IDs		2EKO 2OU2 4QQG	1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 2Z4J 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW 4K7A 4OEA 4OED 4OEY 4OEZ 4OFR 4OFU 4OGH 4OH5 4OH6 4OHA 4OIL 4OIU 4OJ9 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM 4QL8 5CJ6 5JJM 5T8E 5T8J 5V8Q 5VO4
Enriched GO Terms of Interacting Partners?
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