AR and CALR

Number of citations of the paper that reports this interaction (PubMedID 8107809)
75

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		AR	CALR
Description		androgen receptor	calreticulin
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Protein-containing Complex	Acrosomal Vesicle Extracellular Region Extracellular Space Cell Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Basal Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Androgen Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Transcription Regulatory Region DNA Binding ATPase Binding POU Domain Binding	Complement Component C1q Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Systemic Arterial Blood Pressure Epithelial Cell Morphogenesis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Spermatogenesis Single Fertilization Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Protein Deubiquitination Male Somatic Sex Determination Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Leydig Cell Differentiation Multicellular Organism Growth Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Developmental Growth Animal Organ Formation Male Genitalia Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Prostate Induction By Androgen Receptor Signaling Pathway Morphogenesis Of An Epithelial Fold Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Testosterone Stimulus Seminiferous Tubule Development Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ATF6-mediated Unfolded Protein Response Regulation Of Meiotic Nuclear Division Response To Drug Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation	ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Flutamide Oxandrolone Fluphenazine Testosterone Mitotane Estrone Nilutamide Tamoxifen Fludrocortisone Drostanolone Norgestimate Nandrolone phenpropionate Ketoconazole Acetophenazine Bicalutamide Fluoxymesterone Drospirenone Danazol Testosterone Propionate Oxybenzone Delta1-dihydrotestosterone Boldenone Calusterone Propericiazine Prasterone Flufenamic Acid Dihydrotestosterone (R)-Bicalutamide Methyltrienolone (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Cyproterone acetate LGD2941 Oxymetholone Methyltestosterone Norelgestromin 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL Triclosan Nandrolone decanoate Ulipristal Enzalutamide Eugenol Dienogest Norgestrel Homosalate Enzacamene Esculin	Antihemophilic factor, human recombinant Tenecteplase Melatonin Copper Calcium Citrate Calcium Phosphate
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism Prostate cancer Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
GWAS		Balding ( 26926045) Excessive daytime sleepiness ( 27992416) LDL cholesterol ( 19060910) Male-pattern baldness ( 29146897 22693459 27182965 22032556 18849991 28196072) Prostate cancer ( 21743467)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell traits ( 23222517)
Interacting Genes		219 interacting genes: ACTB AHR AKT1 APOL2 APPBP2 ARID5A ATF2 BAG1 BRCA1 CACUL1 CALM1 CALR CASP1 CASP3 CASP7 CASP8 CAV1 CCAR2 CCND1 CCNE1 CCNH CDC25A CDC25B CDC37 CDK1 CDK6 CDK7 CDK9 CEBPA CEBPB CHD8 COX5B CREBBP CTDSP2 CTNNB1 CUL4B DAP3 DAXX DCAF6 DCC DDB2 DDC DENND5A EFCAB6 EGFR ELF3 EP300 ERCC2 ERCC3 ESR1 ETV5 FHL2 FLNA FOXA1 FOXG1 FOXO1 GADD45GIP1 GAK GAPDH GLI2 GRIP1 GSK3B GSN GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 HDAC1 HDAC3 HDAC4 HIF1A HIPK3 HMGB1 HMGB2 HOTAIR HSP90AA1 IARS1 IDE IFI16 IL6ST JMJD1C JUN KAT2B KAT5 KAT7 KDM1A KIF1A KIFAP3 KLK2 LCOR MAGEA11 MAPK1 MDM2 MDN1 MED1 MED12L MED14 MED24 MLH3 MYBBP1A MYLIP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NDE1 NELFCD NFKB1 NISCH NLRP10 NONO NR0B1 NR0B2 NR2C1 NR2C2 NR3C1 NR3C2 NR5A1 NRIP1 NSD1 NSD2 PA2G4 PAK6 PELP1 PIAS1 PIAS2 PIAS3 PIAS4 PNRC1 PNRC2 POU2F1 POU2F2 POU5F1 PRKG1 PRMT1 PRPF6 PSMC3IP PTEN PXN RAC3 RACK1 RAD54L2 RAD9A RAF1 RAN RANBP9 RB1 RBAK RCHY1 REL RELA REPS2 RNASEL RNF14 RNF4 RNF6 RUNX1 RUNX2 SART3 SFPQ SH3YL1 SIRT1 SLC25A4 SMAD1 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCE1 SP1 SPDEF SPOP SRC SREBF1 SRY STAT3 STUB1 SUMO1 SUV39H2 SVIL TADA3 TAF1 TBP TCF20 TCF4 TCF7L2 TDG TGFB1I1 TGIF1 TLE5 TMF1 TNK2 TPD52 TRIM24 TRIP4 TSG101 TXNDC5 UBE2I UBE3A USP10 UXT VCP VHL WIPI1 XRCC5 XRCC6 YWHAQ ZBTB1 ZBTB16 ZBTB32 ZBTB7A ZMIZ1 ZMIZ2 ZNF451	46 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SIRPA SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF
Entrez ID		367	811
HPRD ID		02437	00169
Ensembl ID		ENSG00000169083	ENSG00000179218
Uniprot IDs		A0A087WUX9 F1D8N5 G4VV16 P10275 Q9NUA2	P27797 V9HW88
PDB IDs		1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 2Z4J 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW 4K7A 4OEA 4OED 4OEY 4OEZ 4OFR 4OFU 4OGH 4OH5 4OH6 4OHA 4OIL 4OIU 4OJ9 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM 4QL8 5CJ6 5JJM 5T8E 5T8J 5V8Q 5VO4	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?