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DEAF1 and CDC37
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
114
Data Source:
BioGRID
(two hybrid)
DEAF1
CDC37
Description
DEAF1 transcription factor
cell division cycle 37, HSP90 cochaperone
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Fibrillar Center
Extracellular Region
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Behavioral Fear Response
Neural Tube Closure
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Germ Cell Development
Visual Learning
Anatomical Structure Morphogenesis
Regulation Of Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Embryonic Skeletal System Development
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
ERBB2 Signaling Pathway
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Downregulation of ERBB2 signaling
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
21833088
)
Interacting Genes
19 interacting genes:
AIMP2
ASCC2
CDC37
CDKN1A
CDKN2A
FHL1
GOLGA3
GSK3A
GSK3B
HRAS
INTS1
LMO4
PELI2
PIN1
PPP1CA
PPP1CC
RAD23B
RIDA
TK1
75 interacting genes:
A2M
AKT1
APOE
APP
AR
BTBD10
C19orf44
CC2D1A
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CYP2C9
DCTN1
DEAF1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
EXOSC1
FBXL12
FBXW4
GCDH
GCH1
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IMMT
LONP1
LOXL4
LUC7L2
MAP3K14
MAP3K3
MTOR
MZT2B
NCOA5
NOS3
NR2C2
OGA
PPHLN1
PPP5C
PRAM1
PRDX2
PRMT1
PSME1
PTGES3
RAD23A
RAF1
RNF32
RPS15A
SAFB
SNX5
SPTBN4
SRC
STAMBPL1
STIP1
STK11
TBK1
UBE2I
ZNF205
ZNF235
ZNF266
ZNF667
Entrez ID
10522
11140
HPRD ID
04027
05456
Ensembl ID
ENSG00000177030
ENSG00000105401
Uniprot IDs
O75398
A0A024R7B7
Q16543
PDB IDs
2JW6
4A24
5UWW
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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