TACC3 and EIF3C

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		TACC3	EIF3C
Description		transforming acidic coiled-coil containing protein 3	eukaryotic translation initiation factor 3 subunit C
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways		NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Bladder cancer ( 24163127 20972438) Urinary bladder cancer ( 20348956)	Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Interacting Genes		16 interacting genes: AKAP9 ARNT ARNT2 ASPSCR1 AURKA CIB3 CLIP4 EIF3C KAT2A KIZ NDEL1 NOD2 SNX20 TBC1D22B TTF2 VPS37C	17 interacting genes: AAGAB ALKBH4 BCKDK CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 TACC3
Entrez ID		10460	8663
HPRD ID		05601	04889
Ensembl ID		ENSG00000013810	ENSG00000184110
Uniprot IDs		Q9Y6A5	A0A024QYU9 Q99613
PDB IDs		5LXN 5LXO 5ODS 5ODT	3J8B 3J8C
Enriched GO Terms of Interacting Partners?
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