TACC3 and VPS37C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TACC3	VPS37C
Description		transforming acidic coiled-coil containing protein 3	VPS37C subunit of ESCRT-I
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle	ESCRT I Complex Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Host Cell Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis	Protein Targeting To Membrane Protein Targeting To Vacuole Endosomal Transport Macroautophagy Viral Life Cycle Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus
Pathways		NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Bladder cancer ( 24163127 20972438) Urinary bladder cancer ( 20348956)	Rheumatoid arthritis ( 23143596)
Interacting Genes		16 interacting genes: AKAP9 ARNT ARNT2 ASPSCR1 AURKA CIB3 CLIP4 EIF3C KAT2A KIZ NDEL1 NOD2 SNX20 TBC1D22B TTF2 VPS37C	32 interacting genes: ABI2 APP C1orf94 CEP55 DAZAP2 DDIT3 FAM168A GOLGA2 HGS HNRNPUL1 MAPK1IP1L PDCD6 PDCD6IP PKNOX1 PLSCR1 PSMA3 RBPMS RFX6 RINT1 SH3GL1 SORBS2 SORBS3 STAM2 TACC3 TFG TFIP11 TLE5 TSG101 UBC VPS28 WWP2 XIAP
Entrez ID		10460	55048
HPRD ID		05601	15652
Ensembl ID		ENSG00000013810	ENSG00000167987
Uniprot IDs		Q9Y6A5	A5D8V6
PDB IDs		5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?
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