HAX1 and ABCB11

Number of citations of the paper that reports this interaction (PubMedID 15159385)
24

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		HAX1	ABCB11
Description		HCLS1 associated protein X-1	ATP binding cassette subfamily B member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Apical Part Of Cell Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	Transporter Activity ATP Binding Sodium-exporting ATPase Activity, Phosphorylative Mechanism Canalicular Bile Acid Transmembrane Transporter Activity Bile Acid-exporting ATPase Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Bile Acid Biosynthetic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Sodium Ion Transmembrane Transport Transmembrane Transport
Pathways			Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2
Drugs			ATP Clofazimine Glyburide
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)	Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Gamma glutamyl transferase levels ( 29403010) Glycated hemoglobin levels ( 24647736 20858683 31213470 29170429) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 21909109) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1	3 interacting genes: HAX1 LY6D NR4A1
Entrez ID		10456	8647
HPRD ID		12075	04436
Ensembl ID		ENSG00000143575	ENSG00000073734
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	O95342
PDB IDs
Enriched GO Terms of Interacting Partners?
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