HAX1 and RNF217

Number of citations of the paper that reports this interaction (PubMedID 25298122)
2

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		HAX1	RNF217
Description		HCLS1 associated protein X-1	ring finger protein 217
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane	Ubiquitin Ligase Complex Cytoplasm Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)	Rosacea symptom severity ( 29771307)
Interacting Genes		26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1	1 interacting genes: HAX1
Entrez ID		10456	154214
HPRD ID		12075	17125
Ensembl ID		ENSG00000143575	ENSG00000146373
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	B3KVC8 Q8TC41
PDB IDs
Enriched GO Terms of Interacting Partners?
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