CDR2 and CDC20

Number of citations of the paper that reports this interaction (PubMedID 20383333)
15

Data Source:
BioGRID (enzymatic study)

		CDR2	CDC20
Description		cerebellar degeneration related protein 2	cell division cycle 20
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Spindle Pole Nucleoplasm Anaphase-promoting Complex Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein C-terminus Binding Anaphase-promoting Complex Binding Enzyme Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Regulation Of Dendrite Development Cell Division Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways			Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)
Interacting Genes		43 interacting genes: AMOTL2 ANKRD36BP1 ARNT2 C1orf216 C2CD6 C4orf46 CCDC153 CCHCR1 CDC20 CEP57L1 CHIC2 COX5B EIF4E2 ELOB ENKD1 FAM110A FAM161A FZR1 GMPPA HAUS1 HDAC4 HGS KANSL1 KIFC3 LENG1 LIN37 MORF4L2 MRPL28 NDN NTAQ1 PKN1 RCOR3 RSPH14 SCNM1 SH2D4A SMARCE1 TBC1D22B TCHP TMCC2 TRIM23 TTR TXLNA ZGPAT	46 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CCT5 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L1BP MAD2L2 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 TP63 TRIP13 UBC UBE2C UBE2S
Entrez ID		1039	991
HPRD ID		06681	04686
Ensembl ID		ENSG00000140743	ENSG00000117399
Uniprot IDs		Q01850	Q12834
PDB IDs			4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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