CDR2 and KANSL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CDR2	KANSL1
Description		cerebellar degeneration related protein 2	KAT8 regulatory NSL complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm NSL Complex MLL1 Complex
	Molecular Function	Molecular_function Protein Binding	Protein Binding Histone Acetyltransferase Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process		Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS			Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Automobile speeding propensity ( 30643258) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive function ( 28093568) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General factor of neuroticism ( 30867560) Hand grip strength ( 29313844) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neuroticism ( 29255261) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Parkinson's disease ( 31660654 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pulse pressure ( 27841878) Reaction time ( 29844566) Red blood cell count ( 29403010) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ventral diencephalon volume ( 31530798)
Interacting Genes		43 interacting genes: AMOTL2 ANKRD36BP1 ARNT2 C1orf216 C2CD6 C4orf46 CCDC153 CCHCR1 CDC20 CEP57L1 CHIC2 COX5B EIF4E2 ELOB ENKD1 FAM110A FAM161A FZR1 GMPPA HAUS1 HDAC4 HGS KANSL1 KIFC3 LENG1 LIN37 MORF4L2 MRPL28 NDN NTAQ1 PKN1 RCOR3 RSPH14 SCNM1 SH2D4A SMARCE1 TBC1D22B TCHP TMCC2 TRIM23 TTR TXLNA ZGPAT	35 interacting genes: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 HSPB1 KAT8 KDM1A KIFC3 KRT15 MAGEA12 MDFI NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 RETREG3 SMAD3 SPAG5 TFIP11 TRAF2 TRAF4 TRIM27 USHBP1 WDR5
Entrez ID		1039	284058
HPRD ID		06681	11254
Ensembl ID		ENSG00000140743	ENSG00000120071
Uniprot IDs		Q01850	A0A024R9Y2 A0A1W2PRB5 Q7Z3B3
PDB IDs			4CY1 4CY2
Enriched GO Terms of Interacting Partners?
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