LAMC3 and CFB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LAMC3	CFB
Description		laminin subunit gamma 3	complement factor B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Membrane Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Structural Molecule Activity	Complement Binding Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Visual Perception Animal Organ Morphogenesis Tissue Development Astrocyte Development Cell Migration Extracellular Matrix Organization Substrate Adhesion-dependent Cell Spreading Retina Development In Camera-type Eye	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs			Zinc 4-Guanidinobenzoic Acid Diisopropylphosphono Group
Diseases			Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Alcohol consumption (max-drinks) ( 29460428) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Degraded stimulus continuous performance test score ( 31596458) Endometriosis ( 28333195) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 27749845) Smoking status (heavy vs never) ( 26423011)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160	5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2
Entrez ID		10319	629
HPRD ID		05069	00718
Ensembl ID		ENSG00000050555	ENSG00000243649
Uniprot IDs		Q8N2D6 Q9Y6N6	A0A1U9X7H8 P00751
PDB IDs			1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV
Enriched GO Terms of Interacting Partners?
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