DENND4A and CEBPE

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		DENND4A	CEBPE
Description		DENN domain containing 4A	CCAAT enhancer binding protein epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nuclear Chromatin Nucleus
	Molecular Function	DNA Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Phagocytosis Defense Response Macrophage Differentiation Granulocyte Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide
Pathways		RAB GEFs exchange GTP for GDP on RABs	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hemoglobin concentration ( 27863252) Intelligence (MTAG) ( 29326435) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 29403010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 23512250 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 27863252 28158719)
Interacting Genes		6 interacting genes: CEBPE CLK1 PCBD1 SERTAD1 TLX3 YWHAG	45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		10260	1053
HPRD ID		02662	02852
Ensembl ID		ENSG00000174485	ENSG00000092067
Uniprot IDs		Q05C90 Q7Z401	Q15744
PDB IDs			3T92
Enriched GO Terms of Interacting Partners?
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