CDK9 and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 14580347)
216

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		CDK9	HEXIM1
Description		cyclin dependent kinase 9	HEXIM P-TEFb complex subunit 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nuclear Chromatin Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane PML Body Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Protein Kinase Binding Cyclin Binding Transcription Regulatory Region DNA Binding 7SK SnRNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Regulation Of Mitotic Cell Cycle Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Histone Modification Replication Fork Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Phosphorylation Response To Drug SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Muscle Cell Differentiation Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Negative Regulation Of MRNA Polyadenylation Positive Regulation Of MRNA 3'-UTR Binding Positive Regulation Of Histone H2B Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs		Alvocidib
Diseases
GWAS		Body mass index ( 26426971)	Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		57 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CEBPB CTDP1 CTDSPL CUL1 DHX30 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 MYC NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6	10 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		1025	10614
HPRD ID		16016	09544
Ensembl ID		ENSG00000136807	ENSG00000186834
Uniprot IDs		A0A024R880 P50750	O94992
PDB IDs		1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH	2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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