GPHN and ARHGEF9

Number of citations of the paper that reports this interaction (PubMedID 10607391)
83

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		GPHN	ARHGEF9
Description		gephyrin	Cdc42 guanine nucleotide exchange factor 9
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Cell Junction Dendrite Postsynaptic Membrane Postsynaptic Specialization Postsynaptic Specialization Membrane	Cytosol Postsynaptic Density Cell Junction
	Molecular Function	Protein Binding ATP Binding Nitrate Reductase Activity Molybdopterin Cofactor Binding Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Oxidation-reduction Process Glycine Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Postsynaptic Neurotransmitter Receptor Diffusion Trapping	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Molybdenum cofactor biosynthesis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation GABA receptor activation
Drugs		Formic Acid Imidazole Propanoic Acid
Diseases		Hyperekplexia	Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)	Male-pattern baldness ( 28196072)
Interacting Genes		13 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MTOR PFN1 PIN1 SPATS1 TUBA4A	7 interacting genes: BCL6 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TFIP11
Entrez ID		10243	23229
HPRD ID		04893	02337
Ensembl ID		ENSG00000171723	ENSG00000131089
Uniprot IDs		Q9NQX3	B1AMR3 O43307
PDB IDs		1JLJ	2YSQ
Enriched GO Terms of Interacting Partners?
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