PDIA6 and LGALS9

Number of citations of the paper that reports this interaction (PubMedID 21670307)
76

Data Source:
BioGRID (pull down)

		PDIA6	LGALS9
Description		protein disulfide isomerase family A member 6	galectin 9
Image
GO Annotations	Cellular Component	Extracellular Space Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Collagen-containing Extracellular Matrix
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Peptide Disulfide Oxidoreductase Activity	Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Disaccharide Binding
	Biological Process	Protein Folding IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Oxidation-reduction Process	Natural Killer Cell Tolerance Induction Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Interferon-gamma Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Interleukin-2 family signaling
Drugs			(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Irritable mood ( 29500382)
Interacting Genes		14 interacting genes: ATP13A2 CASP8 CEP250 CLN8 CSNK2A1 LGALS9 MTNR1A MTNR1B NPC2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1	3 interacting genes: P4HB PDIA3 PDIA6
Entrez ID		10130	3965
HPRD ID		07504	03528
Ensembl ID		ENSG00000143870	ENSG00000168961
Uniprot IDs		A0A384NPU5 Q15084	A0A024QZ02 A0A024QZ55 O00182
PDB IDs		1X5D 3VWW 3W8J 4EF0 4GWR	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6
Enriched GO Terms of Interacting Partners?
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