LGALS9 and PDIA3

Number of citations of the paper that reports this interaction (PubMedID 21670307)
76

Data Source:
BioGRID (pull down)

		LGALS9	PDIA3
Description		galectin 9	protein disulfide isomerase family A member 3
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Collagen-containing Extracellular Matrix	Extracellular Space Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Disaccharide Binding	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Natural Killer Cell Tolerance Induction Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Interferon-gamma Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-2 family signaling	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol	Zinc Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Irritable mood ( 29500382)	Blood protein levels ( 30072576) Lead levels ( 26025379)
Interacting Genes		3 interacting genes: P4HB PDIA3 PDIA6	20 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LGALS9 MDM2 MTNR1B SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A
Entrez ID		3965	2923
HPRD ID		03528	03625
Ensembl ID		ENSG00000168961	ENSG00000167004
Uniprot IDs		A0A024QZ02 A0A024QZ55 O00182	P30101 V9HVY3
PDB IDs		2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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