CDH15 and GNA12

Number of citations of the paper that reports this interaction (PubMedID 11136230)
46

Data Source:
HPRD (in vitro, two hybrid)

		CDH15	GNA12
Description		cadherin 15	G protein subunit alpha 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Adherens Junction Cell Surface Integral Component Of Membrane Catenin Complex Neuromuscular Junction Extracellular Exosome	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cadherin Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Muscle Cell Differentiation Cell-cell Adhesion	In Utero Embryonic Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis
Pathways		Adherens junctions interactions Myogenesis Myogenesis	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS			Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		10 interacting genes: ARVCF BOC CDH7 CDH9 CDON CTNNA1 CTNNB1 GNA12 JUP SGTA	29 interacting genes: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		1013	2768
HPRD ID		00225	05093
Ensembl ID		ENSG00000129910	ENSG00000146535
Uniprot IDs		P55291	E9PC54 Q03113 Q6ZQV4
PDB IDs
Enriched GO Terms of Interacting Partners?
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