ARPC4 and ACTR3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ARPC4	ACTR3
Description		actin related protein 2/3 complex subunit 4	actin related protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome	Cell Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Actin Cortical Patch Site Of Double-strand Break Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Binding, Bridging Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Interferon-gamma
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		11 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 NELFCD PNMA5 RNF130	16 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN HCLS1 JUND SHARPIN UBE3A WASF1 WASF2 WASF3 WASL
Entrez ID		10093	10096
HPRD ID		10368	05024
Ensembl ID		ENSG00000241553	ENSG00000115091
Uniprot IDs		P59998	A0A024RAI1 B4DXW1 P61158
PDB IDs
Enriched GO Terms of Interacting Partners?
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