| Novel |
CDC20
|
cell division cycle 20 |
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
- Inactivation of APC/C via direct inhibition of the APC/C complex
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- APC/C:Cdc20 mediated degradation of Cyclin B
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of Emi1
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Ub-specific processing proteases
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
- Antigen processing: Ubiquitination & Proteasome degradation
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| Novel |
CNTRL
|
centriolin |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
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| Novel |
ENG
|
endoglin |
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- Hereditary hemorrhagic telangiectasia (HHT)
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| Novel |
SCAMP1
|
secretory carrier membrane protein 1 |
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| Novel |
SPTAN1
|
spectrin alpha, non-erythrocytic 1 |
- Caspase-mediated cleavage of cytoskeletal proteins
- Nephrin family interactions
- NCAM signaling for neurite out-growth
- NCAM signaling for neurite out-growth
- Interaction between L1 and Ankyrins
- Interaction between L1 and Ankyrins
- RAF/MAP kinase cascade
- Neutrophil degranulation
- COPI-mediated anterograde transport
- RHOU GTPase cycle
- RHOV GTPase cycle
- Sensory processing of sound by inner hair cells of the cochlea
- Sensory processing of sound by outer hair cells of the cochlea
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- Early infantile epileptic encephalopathy; Ohtahara syndrome
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A1CF
|
APOBEC1 complementation factor |
- mRNA Editing: C to U Conversion
- Formation of the Editosome
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ABHD17A
|
abhydrolase domain containing 17A, depalmitoylase |
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ACTN3
|
actinin alpha 3 |
- Nephrin family interactions
- Striated Muscle Contraction
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AIRIM
|
AFG2 interacting ribosome maturation factor |
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AKAP17A
|
A-kinase anchoring protein 17A |
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AQP1
|
aquaporin 1 (Colton blood group) |
- Erythrocytes take up carbon dioxide and release oxygen
- Erythrocytes take up oxygen and release carbon dioxide
- Vasopressin regulates renal water homeostasis via Aquaporins
- Passive transport by Aquaporins
- Developmental Lineage of Pancreatic Ductal Cells
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- Acetazolamide
- B-nonylglucoside
- Mersalyl
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ARID5A
|
AT-rich interaction domain 5A |
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ARNT2
|
aryl hydrocarbon receptor nuclear translocator 2 |
- PPARA activates gene expression
- Phase I - Functionalization of compounds
- Endogenous sterols
- Xenobiotics
- Aryl hydrocarbon receptor signalling
- NPAS4 regulates expression of target genes
- NPAS4 regulates expression of target genes
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ARSJ
|
arylsulfatase family member J |
- The activation of arylsulfatases
- Glycosphingolipid catabolism
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BARD1
|
BRCA1 associated RING domain 1 |
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- UCH proteinases
- Metalloprotease DUBs
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Defective DNA double strand break response due to BRCA1 loss of function
- Defective DNA double strand break response due to BARD1 loss of function
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
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BCAS2
|
BCAS2 pre-mRNA processing factor |
- mRNA Splicing - Major Pathway
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BCL6
|
BCL6 transcription repressor |
- Interleukin-4 and Interleukin-13 signaling
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- FOXO-mediated transcription of cell death genes
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BEX2
|
brain expressed X-linked 2 |
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BEX3
|
brain expressed X-linked 3 |
- NADE modulates death signalling
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BIRC2
|
baculoviral IAP repeat containing 2 |
- Apoptotic cleavage of cellular proteins
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIPK1-mediated regulated necrosis
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- IKK complex recruitment mediated by RIP1
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