TCF12 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACTB	actin beta	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Quercetin Phenethyl Isothiocyanate	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
Novel	ADAM10	ADAM metallopeptidase domain 10	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation	XL784
Novel	BCL2L10	BCL2 like 10
Novel	MAPK6	mitogen-activated protein kinase 6	MAPK6/MAPK4 signaling	Acetylsalicylic acid Minocycline Colforsin
Novel	RSL24D1	ribosomal L24 domain containing 1		(S)-3-phenyllactic acid Anisomycin Puromycin
Novel	SCG3	secretogranin III	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Novel	SLC12A1	solute carrier family 12 member 1	Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)	Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide	Bartter syndrome
Novel	SLC24A1	solute carrier family 24 member 1	Activation of the phototransduction cascade Sodium/Calcium exchangers Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Novel	SPTBN5	spectrin beta, non-erythrocytic 5	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Novel	YKT6	YKT6 vesicular SNARE protein	COPII-mediated vesicle transport COPI-mediated anterograde transport Intra-Golgi traffic RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
	AIRIM	AFG2 interacting ribosome maturation factor
	ARL16	ARF like GTPase 16
	ARMC8	armadillo repeat containing 8	Neutrophil degranulation Regulation of pyruvate metabolism
	ASCL4	achaete-scute family bHLH transcription factor 4
	BMERB1	bMERB domain containing 1
	BMF	Bcl2 modifying factor	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
	CDKN2C	cyclin dependent kinase inhibitor 2C	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
	CFAP206	cilia and flagella associated protein 206
	CKS1B	CDC28 protein kinase regulatory subunit 1B	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
	CLCNKA	chloride voltage-gated channel Ka	Stimuli-sensing channels	Niflumic acid Talniflumate	Bartter syndrome

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