PLEKHF2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF1 fusions FGFR2 alternative splicing
Novel	FOXA1	forkhead box A1	Estrogen-dependent gene expression Formation of axial mesoderm
Novel	HEY1	hes related family bHLH transcription factor with YRPW motif 1	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Novel	NKG7	natural killer cell granule protein 7
Novel	PDP1	pyruvate dehydrogenase phosphatase catalytic subunit 1	Regulation of pyruvate dehydrogenase (PDH) complex		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
Novel	PEX2	peroxisomal biogenesis factor 2	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
Novel	RAB39A	RAB39A, member RAS oncogene family	Intra-Golgi traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Novel	TCN2	transcobalamin 2	Defective TCN2 causes TCN2 deficiency Defective CD320 causes MMATC Transport of RCbl within the body
	ABCG4	ATP binding cassette subfamily G member 4	ABC transporters in lipid homeostasis
	ACY3	aminoacylase 3	Aflatoxin activation and detoxification
	ADAP1	ArfGAP with dual PH domains 1	Nuclear signaling by ERBB4
	AIDA	axin interactor, dorsalization associated
	AIMP2	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
	ANO9	anoctamin 9	Stimuli-sensing channels Induction of Cell-Cell Fusion
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	Alzheimer's disease (AD)
	APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Caspase activation via Dependence Receptors in the absence of ligand
	ARID4B	AT-rich interaction domain 4B	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
	ARL14EP	ARF like GTPase 14 effector protein
	ASPH	aspartate beta-hydroxylase	Stimuli-sensing channels Ion homeostasis Protein hydroxylation	Aspartic acid
	BARHL2	BarH like homeobox 2

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