OIT3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
Novel	ANAPC16	anaphase promoting complex subunit 16	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Novel	ESYT1	extended synaptotagmin 1	RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Glycosphingolipid transport
Novel	PLA2G12B	phospholipase A2 group XIIB
Novel	TBATA	thymus, brain and testes associated
Novel	TYSND1	trypsin like peroxisomal matrix peptidase 1	Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins TYSND1 cleaves peroxisomal proteins
Novel	UNC5B	unc-5 netrin receptor B	Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand
	CRCT1	cysteine rich C-terminal 1
	FBXO34	F-box protein 34
	HOXA1	homeobox A1	Activation of anterior HOX genes in hindbrain development during early embryogenesis	Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
	KRTAP11-1	keratin associated protein 11-1	Keratinization
	LCE1C	late cornified envelope 1C	Formation of the cornified envelope
	LCE1F	late cornified envelope 1F	Formation of the cornified envelope
	LCE3A	late cornified envelope 3A	Formation of the cornified envelope
	MEOX2	mesenchyme homeobox 2
	VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane

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