OIT3 and UNC5B

		OIT3	UNC5B
Description		oncoprotein induced transcript 3	unc-5 netrin receptor B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cell Surface	Plasma Membrane Membrane Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding	Netrin Receptor Activity Protein Binding
	Biological Process	Renal System Process	Angiogenesis Apoptotic Process Signal Transduction Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Low density lipoprotein cholesterol levels ( 29403010 33339817) Refractive error ( 32231278) Total cholesterol levels ( 29403010 33339817)	Attention deficit hyperactivity disorder ( 18839057) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 33772158) Diisocyanate-induced asthma ( 25918132) Problematic alcohol use ( 32451486) Vitiligo ( 22951725)
Interacting Genes		9 interacting genes: CRCT1 FBXO34 HOXA1 KRTAP11-1 LCE1C LCE1F LCE3A MEOX2 VAC14	4 interacting genes: DAPK1 FLRT3 PPP2R1B TREM2
Entrez ID		170392	219699
HPRD ID		17660	08487
Ensembl ID		ENSG00000138315	ENSG00000107731
Uniprot IDs		Q8WWZ8	Q8IZJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development	DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Response To Axon Injury Proepicardium Cell Migration Involved In Pericardium Morphogenesis Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Regulation Of NMDA Receptor Activity Meiotic Sister Chromatid Cohesion, Centromeric Response To Wounding Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Fat Cell Proliferation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of CD40 Signaling Pathway Positive Regulation Of CAMKK-AMPK Signaling Cascade Respiratory Burst After Phagocytosis Negative Regulation Of Autophagic Cell Death Positive Regulation Of Complement Activation Detection Of Lipopolysaccharide Complement-mediated Synapse Pruning Positive Regulation Of Microglial Cell Migration Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Apolipoprotein A-I Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Microglial Cell Activation Involved In Immune Response Regulation Of Astrocyte Activation Very-low-density Lipoprotein Particle Binding Positive Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Hippocampal Neuron Apoptotic Process Detection Of Peptidoglycan Negative Regulation Of Triglyceride Storage Lipoteichoic Acid Binding Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Growth Cone Membrane Synapse Organization Positive Regulation Of Microglial Cell Activation Lipoprotein Particle Binding
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