| Novel |
ACACA
|
acetyl-CoA carboxylase alpha |
- ChREBP activates metabolic gene expression
- Biotin transport and metabolism
- Carnitine shuttle
- Activation of gene expression by SREBF (SREBP)
- Defective HLCS causes multiple carboxylase deficiency
- Fatty acyl-CoA biosynthesis
|
|
|
| Novel |
ALPP
|
alkaline phosphatase, placental |
|
- Calcium
- METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
|
|
| Novel |
ANXA11
|
annexin A11 |
|
|
|
| Novel |
ARF5
|
ARF GTPase 5 |
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
|
|
|
| Novel |
ATP6V0A2
|
ATPase H+ transporting V0 subunit a2 |
- ROS and RNS production in phagocytes
- Insulin receptor recycling
- Transferrin endocytosis and recycling
- Ion channel transport
|
|
- Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
|
| Novel |
CABP1
|
calcium binding protein 1 |
- Sensory processing of sound by inner hair cells of the cochlea
|
|
|
| Novel |
GSK3A
|
glycogen synthase kinase 3 alpha |
- AKT phosphorylates targets in the cytosol
- XBP1(S) activates chaperone genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Suppression of apoptosis
- Maturation of nucleoprotein
- Maturation of nucleoprotein
|
|
|
| Novel |
HCAR3
|
hydroxycarboxylic acid receptor 3 |
- Hydroxycarboxylic acid-binding receptors
- G alpha (i) signalling events
|
- Niacin
- Inositol nicotinate
|
|
| Novel |
KNTC1
|
kinetochore associated 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
|
|
|
| Novel |
MLEC
|
malectin |
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Neutrophil degranulation
|
|
|
| Novel |
MRPL19
|
mitochondrial ribosomal protein L19 |
- Mitochondrial translation initiation
- Mitochondrial translation elongation
- Mitochondrial translation elongation
- Mitochondrial translation termination
- Mitochondrial ribosome-associated quality control
|
|
|
| Novel |
RAB35
|
RAB35, member RAS oncogene family |
- TBC/RABGAPs
- RAB geranylgeranylation
- RAB GEFs exchange GTP for GDP on RABs
|
|
|
| Novel |
SNRNP35
|
small nuclear ribonucleoprotein U11/U12 subunit 35 |
- mRNA Splicing - Minor Pathway
|
|
|
| Novel |
SRSF9
|
serine and arginine rich splicing factor 9 |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA Splicing - Major Pathway
- mRNA 3'-end processing
- Processing of Capped Intron-Containing Pre-mRNA
- RNA Polymerase II Transcription Termination
|
|
|
| Novel |
TRA2A
|
transformer 2 alpha homolog |
|
|
|
|
SVIL
|
supervillin |
|
|
|
|
YWHAG
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- AURKA Activation by TPX2
- Regulation of localization of FOXO transcription factors
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways
- Transcriptional and post-translational regulation of MITF-M expression and activity
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
|
|
|
|
YWHAZ
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Deactivation of the beta-catenin transactivating complex
- Rap1 signalling
- GP1b-IX-V activation signalling
- KSRP (KHSRP) binds and destabilizes mRNA
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Negative regulation of NOTCH4 signaling
- Regulation of localization of FOXO transcription factors
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways
- Transcriptional and post-translational regulation of MITF-M expression and activity
|
|
|