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Novel |
ATG10 |
autophagy related 10 |
- Macroautophagy
- Macroautophagy
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Novel |
CDKN2A |
cyclin dependent kinase inhibitor 2A |
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
- Transcriptional Regulation by VENTX
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Apoptotic factor-mediated response
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- Regulation of TP53 Degradation
- Stabilization of p53
- Regulation of RUNX3 expression and activity
- Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
- Evasion of Oncogene Induced Senescence Due to p14ARF Defects
- Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
- Nuclear events mediated by NFE2L2
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- Chronic myeloid leukemia (CML)
- Non-small cell lung cancer
- Malignant islet cell carcinoma
- Adult T-cell leukemia
- Esophageal cancer
- Glioma
- Pancreatic cancer
- Nasopharyngeal cancer
- Hepatocellular carcinoma
- Squamous cell carcinoma
- Penile cancer
- Oral cancer
- Malignant melanoma
- Burkitt lymphoma
- Gallbladder cancer
- Bladder cancer
- Laryngeal cancer
- Cholangiocarcinoma
- Malignant pleural mesothelioma
- Osteosarcoma
- Type II diabetes mellitus
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Novel |
EEF1AKMT3 |
EEF1A lysine methyltransferase 3 |
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|
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Novel |
GLDC |
glycine decarboxylase |
|
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- Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
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Novel |
NPR2 |
natriuretic peptide receptor 2 |
|
- Erythrityl tetranitrate
- Nesiritide
- Vosoritide
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- Acromesomelic dysplasia, Maroteaux type
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|
Novel |
ZIC3 |
Zic family zinc finger 3 |
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Transcriptional regulation of pluripotent stem cells
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- Heterotaxy; Situs ambiguus
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PAFAH1B1 |
platelet activating factor acetylhydrolase 1b regulatory subunit 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
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- Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
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SQSTM1 |
sequestosome 1 |
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- PINK1-PRKN Mediated Mitophagy
- Neddylation
- Interleukin-1 signaling
- Pexophagy
- Signaling by ALK fusions and activated point mutants
- KEAP1-NFE2L2 pathway
- Nuclear events mediated by NFE2L2
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- Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
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