DNAI1 and GLDC

		DNAI1	GLDC
Description		dynein axonemal intermediate chain 1	glycine decarboxylase
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Dynein Complex Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Dynein Axonemal Particle	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Cytoskeletal Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Oxidoreductase Activity Glycine Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Insulin Receptor Signaling Pathway Cell Projection Organization Flagellated Sperm Motility Outer Dynein Arm Assembly	Amino Acid Metabolic Process Glycine Metabolic Process Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Methylamine Response To Lipoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways			Glycine degradation
Drugs			Pyridoxal phosphate
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)	Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 30837465 31070104) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: PAFAH1B1 SQSTM1	2 interacting genes: SIRT3 TLR10
Entrez ID		27019	2731
HPRD ID		05080	01996
Ensembl ID		ENSG00000122735	ENSG00000178445
Uniprot IDs		A0A087WWV9 A0A140VJI0 Q9UI46	P23378
PDB IDs		8J07	6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion DNA-templated Transcription Positive Regulation Of Macrophage Apoptotic Process Nucleobase-containing Compound Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Stem Cell Division Protein K63-linked Ubiquitination Autophagy Cell Population Proliferation Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Apoptotic Process Involved In Mammary Gland Involution Stem Cell Population Maintenance Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Glycine Catabolic Process Response To Methylamine Limb Morphogenesis Cumulus Cell Differentiation Natriuretic Peptide Receptor Activity Vestibulocochlear Nerve Maturation Nerve Maturation C-di-GMP Signaling Granulosa Cell Differentiation Activation Of Meiosis Involved In Egg Activation Neuromuscular Process Gastric Emptying Negative Regulation Of Oocyte Maturation Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Forebrain Development Astral Microtubule Hippocampus Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Mitophagy Brown Fat Cell Proliferation Amphisome Atg12 Transferase Activity Atg12 Conjugating Enzyme Activity Maintenance Of Cell Number Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution	Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Toll-like Receptor 2 Binding Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Histone Deacetylase Activity, NAD-dependent Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cellular Respiration Positive Regulation Of Ceramide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Sphingolipid Biosynthetic Process Dynein Heavy Chain Binding Dynein Light Chain Binding Outer Dynein Arm Cellular Response To Bacterial Lipopeptide NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding Response To Bacterial Lipoprotein NAD+ Binding Regulation Of Oxidoreductase Activity Dynein Axonemal Particle Outer Dynein Arm Assembly Regulation Of Membrane Lipid Metabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Phosphorylation Cytokine Receptor Binding Macromolecule Deacylation Glial Cell Projection NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Aerobic Respiration Positive Regulation Of Amide Metabolic Process 9+2 Motile Cilium Innate Immune Response Dynein Complex Axonemal Dynein Complex Assembly Response To Exogenous DsRNA Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Reactive Oxygen Species Metabolic Process
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