| Novel |
AGFG1
|
ArfGAP with FG repeats 1 |
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
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| Novel |
FAM124B
|
family with sequence similarity 124 member B |
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| Novel |
GYPA
|
glycophorin A (MNS blood group) |
- Cell surface interactions at the vascular wall
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| Novel |
NDUFA10
|
NADH:ubiquinone oxidoreductase subunit A10 |
- Respiratory electron transport
- Complex I biogenesis
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| Novel |
SRA1
|
steroid receptor RNA activator 1 |
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| Novel |
ZAP70
|
zeta chain of T cell receptor associated protein kinase 70 |
- Translocation of ZAP-70 to Immunological synapse
- Generation of second messenger molecules
- RHOH GTPase cycle
- Nuclear events stimulated by ALK signaling in cancer
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- Staurosporine
- Fostamatinib
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- Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
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ABTB1
|
ankyrin repeat and BTB domain containing 1 |
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ABTB2
|
ankyrin repeat and BTB domain containing 2 |
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ARHGEF12
|
Rho guanine nucleotide exchange factor 12 |
- NRAGE signals death through JNK
- G alpha (12/13) signalling events
- Sema4D induced cell migration and growth-cone collapse
- RHOA GTPase cycle
- RHOB GTPase cycle
- RHOC GTPase cycle
- CDC42 GTPase cycle
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BTBD10
|
BTB domain containing 10 |
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BTBD2
|
BTB domain containing 2 |
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BTBD3
|
BTB domain containing 3 |
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BTBD6
|
BTB domain containing 6 |
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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CAMK1D
|
calcium/calmodulin dependent protein kinase ID |
|
- N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE
- Fostamatinib
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CAND1
|
cullin associated and neddylation dissociated 1 |
- Neutrophil degranulation
- Neddylation
- Iron uptake and transport
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CCND1
|
cyclin D1 |
- SCF(Skp2)-mediated degradation of p27/p21
- Pre-NOTCH Transcription and Translation
- RMTs methylate histone arginines
- Interleukin-4 and Interleukin-13 signaling
- Cyclin D associated events in G1
- Ubiquitin-dependent degradation of Cyclin D
- Ubiquitin-dependent degradation of Cyclin D
- PTK6 Regulates Cell Cycle
- Transcriptional Regulation by VENTX
- Transcriptional regulation by RUNX2
- Regulation of RUNX1 Expression and Activity
- RUNX3 regulates WNT signaling
- RUNX3 regulates p14-ARF
- Estrogen-dependent gene expression
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- Drug-mediated inhibition of CDK4/CDK6 activity
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
|
- Acetylsalicylic acid
- Arsenic trioxide
- Encorafenib
- Bryostatin 1
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- Breast cancer
- Hairy-cell leukemia
- Oral cancer
- Multiple myeloma
- Laryngeal cancer
- von Hippel-Lindau syndrome
- Esophageal cancer
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CCNE1
|
cyclin E1 |
- G0 and Early G1
- SCF(Skp2)-mediated degradation of p27/p21
- DNA Damage/Telomere Stress Induced Senescence
- Association of TriC/CCT with target proteins during biosynthesis
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- CDK-mediated phosphorylation and removal of Cdc6
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- PTK6 Regulates Cell Cycle
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- RHOBTB3 ATPase cycle
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- Laryngeal cancer
- Gastric cancer
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CDC25A
|
cell division cycle 25A |
- Transcription of E2F targets under negative control by DREAM complex
- Polo-like kinase mediated events
- Activation of ATR in response to replication stress
- Ub-specific processing proteases
- Cyclin E associated events during G1/S transition
- Cyclin A/B1/B2 associated events during G2/M transition
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- Cyclin A:Cdk2-associated events at S phase entry
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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CDC34
|
cell division cycle 34, ubiquitin conjugating enzyme |
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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CEBPA
|
CCAAT enhancer binding protein alpha |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
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- Acute myeloid leukemia (AML)
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