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PTEN
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phosphatase and tensin homolog |
- Synthesis of PIPs at the plasma membrane
- Synthesis of IP3 and IP4 in the cytosol
- Negative regulation of the PI3K/AKT network
- Downstream TCR signaling
- TP53 Regulates Metabolic Genes
- PTEN Loss of Function in Cancer
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Regulation of PTEN mRNA translation
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Transcriptional Regulation by MECP2
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- Vulvar cancer
- Breast cancer
- Malignant melanoma
- Prostate cancer
- Hepatocellular carcinoma
- Small cell lung cancer
- Endometrial Cancer
- Glioma
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RHOXF2
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Rhox homeobox family member 2 |
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RNF10
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ring finger protein 10 |
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RPRD2
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regulation of nuclear pre-mRNA domain containing 2 |
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
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SMG1
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SMG1 nonsense mediated mRNA decay associated PI3K related kinase |
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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SMG5
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SMG5 nonsense mediated mRNA decay factor |
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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STAU1
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staufen double-stranded RNA binding protein 1 |
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SUMO2
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small ubiquitin like modifier 2 |
- Vitamin D (calciferol) metabolism
- SUMO is conjugated to E1 (UBA2:SAE1)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is proteolytically processed
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- Regulation of endogenous retroelements by KRAB-ZFP proteins
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UPF2
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UPF2 regulator of nonsense mediated mRNA decay |
- Regulation of expression of SLITs and ROBOs
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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UPF3A
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UPF3A regulator of nonsense mediated mRNA decay |
- Regulation of expression of SLITs and ROBOs
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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UPF3B
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UPF3B regulator of nonsense mediated mRNA decay |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA Splicing - Major Pathway
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
- Regulation of expression of SLITs and ROBOs
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
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XRN1
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5'-3' exoribonuclease 1 |
- mRNA decay by 5' to 3' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
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