PLEKHF2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	Clathrin-mediated endocytosis
PAK1IP1	PAK1 interacting protein 1
PDK4	pyruvate dehydrogenase kinase 4	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Tretinoin 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol
PIK3R3	phosphoinositide-3-kinase regulatory subunit 3	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Co-stimulation by ICOS	SF1126
PPCDC	phosphopantothenoylcysteine decarboxylase	Coenzyme A biosynthesis	Flavin mononucleotide Pantothenoylaminoethenethiol
PPP1R18	protein phosphatase 1 regulatory subunit 18
PRDM14	PR/SET domain 14	Transcriptional regulation of pluripotent stem cells
PRKAG1	protein kinase AMP-activated non-catalytic subunit gamma 1	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Adenosine phosphate Acetylsalicylic acid Fostamatinib
PRKAR1A	protein kinase cAMP-dependent type I regulatory subunit alpha	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231	Pigmented micronodular adrenocortical disease (PPNAD)
PRPSAP1	phosphoribosyl pyrophosphate synthetase associated protein 1
PTPN3	protein tyrosine phosphatase non-receptor type 3	EGFR downregulation Negative regulation of MAPK pathway
PWWP2A	PWWP domain containing 2A
RAB28	RAB28, member RAS oncogene family
RABAC1	Rab acceptor 1
RADX	RPA1 related single stranded DNA binding protein, X-linked
RARA	retinoic acid receptor alpha	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis TGFBR3 expression	Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene	Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
RASGEF1B	RasGEF domain family member 1B
RGS10	regulator of G protein signaling 10	G alpha (i) signalling events G alpha (i) signalling events
RGS8	regulator of G protein signaling 8	G alpha (i) signalling events G alpha (i) signalling events
RPAP2	RNA polymerase II associated protein 2	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes

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