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PRDM14
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PR/SET domain 14 |
- Transcriptional regulation of pluripotent stem cells
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PRDX6
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peroxiredoxin 6 |
- Detoxification of Reactive Oxygen Species
- Neutrophil degranulation
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- 2-(N-morpholino)ethanesulfonic acid
- Copper
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PRKCI
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protein kinase C iota |
- Pre-NOTCH Transcription and Translation
- p75NTR recruits signalling complexes
- Tight junction interactions
- KEAP1-NFE2L2 pathway
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- Tamoxifen
- Staurosporine
- Bisindolylmaleimide I
- Dequalinium
- Benzoyl peroxide
- Fostamatinib
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PRKCZ
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protein kinase C zeta |
- GPVI-mediated activation cascade
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- VEGFR2 mediated cell proliferation
- RHO GTPases Activate NADPH Oxidases
- Estrogen-stimulated signaling through PRKCZ
- Estrogen-stimulated signaling through PRKCZ
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- Tamoxifen
- Staurosporine
- Dequalinium
- Benzoyl peroxide
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PRKN
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parkin RBR E3 ubiquitin protein ligase |
- PINK1-PRKN Mediated Mitophagy
- Regulation of necroptotic cell death
- Josephin domain DUBs
- Aggrephagy
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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PRSS50
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serine protease 50 |
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PSEN1
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presenilin 1 |
- Nuclear signaling by ERBB4
- Degradation of the extracellular matrix
- Regulated proteolysis of p75NTR
- NRIF signals cell death from the nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- EPH-ephrin mediated repulsion of cells
- Neutrophil degranulation
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Noncanonical activation of NOTCH3
- TGFBR3 PTM regulation
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- Alzheimer's disease (AD)
- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
- Acne inversa; Hidradenitis supprativa
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PSEN2
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presenilin 2 |
- Nuclear signaling by ERBB4
- Regulated proteolysis of p75NTR
- NRIF signals cell death from the nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- EPH-ephrin mediated repulsion of cells
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Noncanonical activation of NOTCH3
- TGFBR3 PTM regulation
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PSMC3IP
|
PSMC3 interacting protein |
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QDPR
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quinoid dihydropteridine reductase |
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- NADH
- 2-(N-morpholino)ethanesulfonic acid
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- Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
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RALBP1
|
ralA binding protein 1 |
- CDC42 GTPase cycle
- RAC1 GTPase cycle
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RB1
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RB transcriptional corepressor 1 |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Condensation of Prophase Chromosomes
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- Oncogene Induced Senescence
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- RUNX2 regulates osteoblast differentiation
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- Defective translocation of RB1 mutants to the nucleus
- Replication of the SARS-CoV-1 genome
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Replication of the SARS-CoV-2 genome
- Nuclear events stimulated by ALK signaling in cancer
- Positive Regulation of CDH1 Gene Transcription
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
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- Chronic myeloid leukemia (CML)
- Breast cancer
- Osteosarcoma
- Hepatocellular carcinoma
- Small cell lung cancer
- Esophageal cancer
- Glioma
- Bladder cancer
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RIPK1
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receptor interacting serine/threonine kinase 1 |
- Caspase activation via Death Receptors in the presence of ligand
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- TRIF-mediated programmed cell death
- TRP channels
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Regulation of necroptotic cell death
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Dimerization of procaspase-8
- TNF signaling
- TLR3-mediated TICAM1-dependent programmed cell death
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IKK complex recruitment mediated by RIP1
- Potential therapeutics for SARS
- Microbial modulation of RIPK1-mediated regulated necrosis
- SARS-CoV-1-mediated effects on programmed cell death
- Defective RIPK1-mediated regulated necrosis
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RIPK2
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receptor interacting serine/threonine kinase 2 |
- NOD1/2 Signaling Pathway
- NOD1/2 Signaling Pathway
- Downstream TCR signaling
- p75NTR recruits signalling complexes
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Ovarian tumor domain proteases
- Interleukin-1 signaling
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
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RNF31
|
ring finger protein 31 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
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RYBP
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RING1 and YY1 binding protein |
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Transcriptional Regulation by E2F6
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S100A14
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S100 calcium binding protein A14 |
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SCGB2A2
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secretoglobin family 2A member 2 |
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SERPINB5
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serpin family B member 5 |
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- S,S-(2-Hydroxyethyl)Thiocysteine
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SNRPD3
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small nuclear ribonucleoprotein D3 polypeptide |
- SLBP independent Processing of Histone Pre-mRNAs
- snRNP Assembly
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- RNA Polymerase II Transcription Termination
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
- SARS-CoV-2 modulates host translation machinery
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