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GRAP2
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GRB2 related adaptor protein 2 |
- Signaling by SCF-KIT
- Generation of second messenger molecules
- DAP12 signaling
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- Co-stimulation by CD28
- FLT3 Signaling
- Signaling by CSF1 (M-CSF) in myeloid cells
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HAUS1
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HAUS augmin like complex subunit 1 |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
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HELT
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helt bHLH transcription factor |
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HEY2
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hes related family bHLH transcription factor with YRPW motif 2 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- RUNX2 regulates osteoblast differentiation
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
- Cardiogenesis
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HGS
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hepatocyte growth factor-regulated tyrosine kinase substrate |
- EGFR downregulation
- Lysosome Vesicle Biogenesis
- Ub-specific processing proteases
- Negative regulation of MET activity
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- InlB-mediated entry of Listeria monocytogenes into host cell
- RHOU GTPase cycle
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Inhibition of membrane repair
- Prevention of phagosomal-lysosomal fusion
- RHOBTB3 ATPase cycle
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HIVEP3
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HIVEP zinc finger 3 |
- Regulation of RUNX2 expression and activity
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HMG20B
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high mobility group 20B |
- HDACs deacetylate histones
- Potential therapeutics for SARS
- Factors involved in megakaryocyte development and platelet production
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HNRNPM
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heterogeneous nuclear ribonucleoprotein M |
- FGFR2 alternative splicing
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
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HOXA1
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homeobox A1 |
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
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- Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
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HOXB5
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homeobox B5 |
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HOXC8
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homeobox C8 |
- Regulation of CDH11 gene transcription
- Regulation of CDH11 gene transcription
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HOXD12
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homeobox D12 |
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IKBKB
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inhibitor of nuclear factor kappa B kinase subunit beta |
- Activation of NF-kappaB in B cells
- Activation of NF-kappaB in B cells
- ER-Phagosome pathway
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- Downstream TCR signaling
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- FCERI mediated NF-kB activation
- TAK1-dependent IKK and NF-kappa-B activation
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- IKBKB deficiency causes SCID
- IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
- IkBA variant leads to EDA-ID
- CLEC7A (Dectin-1) signaling
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Regulation of NF-kappa B signaling
- PKR-mediated signaling
- SLC15A4:TASL-dependent IRF5 activation
- Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
- Modulation of host responses by IFN-stimulated genes
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- Mesalazine
- Acetylsalicylic acid
- Auranofin
- Arsenic trioxide
- MLN0415
- Acetylcysteine
- Ertiprotafib
- Fostamatinib
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JOSD1
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Josephin domain containing 1 |
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KANK2
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KN motif and ankyrin repeat domains 2 |
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KIAA1217
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KIAA1217 |
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KIF1A
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kinesin family member 1A |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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- Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
- Phosphoaminophosphonic Acid-Adenylate Ester
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KLHL38
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kelch like family member 38 |
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KPNA2
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karyopherin subunit alpha 2 |
- CaMK IV-mediated phosphorylation of CREB
- ISG15 antiviral mechanism
- NS1 Mediated Effects on Host Pathways
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Sensing of DNA Double Strand Breaks
- Estrogen-dependent gene expression
- SARS-CoV-1 activates/modulates innate immune responses
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
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KRT3
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keratin 3 |
- Keratinization
- Formation of the cornified envelope
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- Meesmann corneal dystrophy
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