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PTPRC |
protein tyrosine phosphatase receptor type C |
- Phosphorylation of CD3 and TCR zeta chains
- Other semaphorin interactions
- Neutrophil degranulation
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- T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
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RAD1 |
RAD1 checkpoint DNA exonuclease |
- Activation of ATR in response to replication stress
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Impaired BRCA2 binding to RAD51
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RAD9A |
RAD9 checkpoint clamp component A |
- Activation of ATR in response to replication stress
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Impaired BRCA2 binding to RAD51
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RELA |
RELA proto-oncogene, NF-kB subunit |
- Activation of NF-kappaB in B cells
- RIP-mediated NFkB activation via ZBP1
- Regulated proteolysis of p75NTR
- Downstream TCR signaling
- NF-kB is activated and signals survival
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- PKMTs methylate histone lysines
- Transcriptional regulation of white adipocyte differentiation
- TAK1-dependent IKK and NF-kappa-B activation
- Interleukin-1 processing
- SUMOylation of immune response proteins
- IkBA variant leads to EDA-ID
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- CD209 (DC-SIGN) signaling
- CLEC7A/inflammasome pathway
- The NLRP3 inflammasome
- Transcriptional Regulation by VENTX
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- Purinergic signaling in leishmaniasis infection
- SARS-CoV-1 activates/modulates innate immune responses
- Regulation of NFE2L2 gene expression
- Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
- Regulation of PD-L1(CD274) transcription
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- Glucosamine
- Dimethyl fumarate
- SC-236
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RGS19 |
regulator of G protein signaling 19 |
- G alpha (q) signalling events
- G alpha (i) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
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SAT1 |
spermidine/spermine N1-acetyltransferase 1 |
- Interconversion of polyamines
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- N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
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- Keratosis follicularis spinulosa decalvans
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SLC18A2 |
solute carrier family 18 member A2 |
- Serotonin Neurotransmitter Release Cycle
- Norepinephrine Neurotransmitter Release Cycle
- Dopamine Neurotransmitter Release Cycle
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- Amphetamine
- Reserpine
- Norepinephrine
- Haloperidol
- Mazindol
- Benzphetamine
- Dopamine
- Deserpidine
- Ephedra sinica root
- MMDA
- Midomafetamine
- 4-Methoxyamphetamine
- Dextroamphetamine
- Metamfetamine
- Nomifensine
- Tetrabenazine
- Histamine
- Isometheptene
- Propylhexedrine
- Serotonin
- Rauwolfia serpentina root
- Deutetrabenazine
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SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SNCA |
synuclein alpha |
- Amyloid fiber formation
- PKR-mediated signaling
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- Resveratrol
- Dequalinium
- Copper
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- Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
- Parkinson's disease (PD)
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SNX6 |
sorting nexin 6 |
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SPIB |
Spi-B transcription factor |
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SPP1 |
secreted phosphoprotein 1 |
- Degradation of the extracellular matrix
- Signaling by PDGF
- Integrin cell surface interactions
- Integrin cell surface interactions
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RUNX3 Regulates Immune Response and Cell Migration
- Post-translational protein phosphorylation
- Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
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STX1A |
syntaxin 1A |
- Serotonin Neurotransmitter Release Cycle
- Norepinephrine Neurotransmitter Release Cycle
- Glutamate Neurotransmitter Release Cycle
- Dopamine Neurotransmitter Release Cycle
- Acetylcholine Neurotransmitter Release Cycle
- Insulin processing
- Regulation of insulin secretion
- Other interleukin signaling
- Toxicity of botulinum toxin type C (botC)
- LGI-ADAM interactions
- Neurexins and neuroligins
- GABA synthesis, release, reuptake and degradation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Sensory processing of sound by inner hair cells of the cochlea
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TCF7L2 |
transcription factor 7 like 2 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Deactivation of the beta-catenin transactivating complex
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
- Ca2+ pathway
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- Repression of WNT target genes
- Repression of WNT target genes
- Signaling by TCF7L2 mutants
- Transcriptional Regulation by VENTX
- RUNX3 regulates WNT signaling
- Formation of definitive endoderm
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Regulation of PD-L1(CD274) transcription
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- Type II diabetes mellitus
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TCOF1 |
treacle ribosome biogenesis factor 1 |
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- Treacher Collins syndrome
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TGFBR1 |
transforming growth factor beta receptor 1 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- Ub-specific processing proteases
- TGFBR3 regulates TGF-beta signaling
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- 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
- Naphthyridine Inhibitor
- 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
- N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
- 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
- N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
- Fostamatinib
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- Loeys-Dietz syndrome (LDS)
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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TGM2 |
transglutaminase 2 |
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- Guanosine-5'-Diphosphate
- Hexylresorcinol
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TOP1 |
DNA topoisomerase I |
- SUMOylation of DNA replication proteins
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- Irinotecan
- Dactinomycin
- Doxorubicin
- Topotecan
- Camptothecin
- Edotecarin
- Lucanthone
- Elsamitrucin
- 7-ethyl-10-hydroxycamptothecin
- Sodium stibogluconate
- Cositecan
- XMT-1001
- Rubitecan
- 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
- 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
- Hexylresorcinol
- Sacituzumab govitecan
- Trastuzumab deruxtecan
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TP63 |
tumor protein p63 |
- Activation of PUMA and translocation to mitochondria
- Pyroptosis
- TP53 Regulates Metabolic Genes
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- Regulation of TP53 Activity through Association with Co-factors
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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- Split-hand/foot malformation (SHFM)
- Limb-mammary syndrome
- Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome)
- ADULT syndrome
- Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
- Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
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TRIM41 |
tripartite motif containing 41 |
- Antigen processing: Ubiquitination & Proteasome degradation
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