Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols CSNK2A2 and SLC18A2	Name 1 casein kinase 2 alpha 2	Name2 solute carrier family 18 member A2	Pathway 1 Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	Drugs 1 [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib	Drugs 2 Amphetamine Reserpine Norepinephrine Haloperidol Mazindol Benzphetamine Dopamine Deserpidine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Nomifensine Tetrabenazine Histamine Isometheptene Propylhexedrine Serotonin Rauwolfia serpentina root Deutetrabenazine	Diseases 1	Diseases 2
Novel Novel	Symbols CALCOCO2 and ARHGEF39	Name 1 calcium binding and coiled-coil domain 2	Name2 Rho guanine nucleotide exchange factor 39	Pathway 1	Pathway 2 NRAGE signals death through JNK G alpha (12/13) signalling events RAC1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BNIP3L and ROBO2	Name 1 BCL2 interacting protein 3 like	Name2 roundabout guidance receptor 2	Pathway 1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Pathway 2 Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Vesicoureteral reflux
Novel Novel	Symbols BNIP3L and CLN8	Name 1 BCL2 interacting protein 3 like	Name2 CLN8 transmembrane ER and ERGIC protein	Pathway 1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ACTB and AQP2	Name 1 actin beta	Name2 aquaporin 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Pathway 2 Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Drugs 1 Quercetin Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	Diseases 2 Congenital nephrogenic diabetes insipidus (NDI)
Novel Novel	Symbols EWSR1 and WDR37	Name 1 EWS RNA binding protein 1	Name2 WD repeat domain 37	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue	Diseases 2
Novel Novel	Symbols PLSCR1 and SPG7	Name 1 phospholipid scramblase 1	Name2 SPG7 matrix AAA peptidase subunit, paraplegin	Pathway 1	Pathway 2 Processing of SMDT1 Mitochondrial protein degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Hereditary spastic paraplegia (SPG)
Novel Novel	Symbols DAZAP2 and RBM43	Name 1 DAZ associated protein 2	Name2 RNA binding motif protein 43	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CBS and SMARCAD1	Name 1 cystathionine beta-synthase	Name2 SNF2 related chromatin remodeling ATPase with DExD box 1	Pathway 1 Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Pathway 2	Drugs 1 Pyridoxal phosphate Ademetionine Serine Cysteine	Drugs 2	Diseases 1 Homocystinuria	Diseases 2
Novel Novel	Symbols TRIP13 and TNRC6A	Name 1 thyroid hormone receptor interactor 13	Name2 trinucleotide repeat containing adaptor 6A	Pathway 1	Pathway 2 Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MDFI and TNP2	Name 1 MyoD family inhibitor	Name2 transition protein 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RBPMS and NYNRIN	Name 1 RNA binding protein, mRNA processing factor	Name2 NYN domain and retroviral integrase containing	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RBPMS and CPEB2	Name 1 RNA binding protein, mRNA processing factor	Name2 cytoplasmic polyadenylation element binding protein 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NEK6 and EML4	Name 1 NIMA related kinase 6	Name2 EMAP like 4	Pathway 1 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Pathway 2 EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Non-small cell lung cancer
Novel Novel	Symbols YWHAG and SRGAP2	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Name2 SLIT-ROBO Rho GTPase activating protein 2	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Pathway 2 Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols YWHAG and TBC1D4	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Name2 TBC1 domain family member 4	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Pathway 2 Translocation of SLC2A4 (GLUT4) to the plasma membrane	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols OTX1 and KCNK16	Name 1 orthodenticle homeobox 1	Name2 potassium two pore domain channel subfamily K member 16	Pathway 1	Pathway 2 TWIK-related alkaline pH activated K+ channel (TALK) Phase 4 - resting membrane potential	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FXR2 and KCNRG	Name 1 FMR1 autosomal homolog 2	Name2 potassium channel regulator	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ANXA11 and PLSCR1	Name 1 annexin A11	Name2 phospholipid scramblase 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP1M1 and LRMDA	Name 1 adaptor related protein complex 1 subunit mu 1	Name2 leucine rich melanocyte differentiation associated	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CSNK2A2 and SLC18A2	Name 1 casein kinase 2 alpha 2	Name2 solute carrier family 18 member A2	Pathway 1 Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	Drugs 1 [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib	Drugs 2 Amphetamine Reserpine Norepinephrine Haloperidol Mazindol Benzphetamine Dopamine Deserpidine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Nomifensine Tetrabenazine Histamine Isometheptene Propylhexedrine Serotonin Rauwolfia serpentina root Deutetrabenazine	Diseases 1	Diseases 2
Novel	Symbols CALCOCO2 and ARHGEF39	Name 1 calcium binding and coiled-coil domain 2	Name2 Rho guanine nucleotide exchange factor 39	Pathway 1	Pathway 2 NRAGE signals death through JNK G alpha (12/13) signalling events RAC1 GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BNIP3L and ROBO2	Name 1 BCL2 interacting protein 3 like	Name2 roundabout guidance receptor 2	Pathway 1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Pathway 2 Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Vesicoureteral reflux
Novel	Symbols BNIP3L and CLN8	Name 1 BCL2 interacting protein 3 like	Name2 CLN8 transmembrane ER and ERGIC protein	Pathway 1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ACTB and AQP2	Name 1 actin beta	Name2 aquaporin 2	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Pathway 2 Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Drugs 1 Quercetin Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	Diseases 2 Congenital nephrogenic diabetes insipidus (NDI)
Novel	Symbols EWSR1 and WDR37	Name 1 EWS RNA binding protein 1	Name2 WD repeat domain 37	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue	Diseases 2
Novel	Symbols PLSCR1 and SPG7	Name 1 phospholipid scramblase 1	Name2 SPG7 matrix AAA peptidase subunit, paraplegin	Pathway 1	Pathway 2 Processing of SMDT1 Mitochondrial protein degradation	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Hereditary spastic paraplegia (SPG)
Novel	Symbols DAZAP2 and RBM43	Name 1 DAZ associated protein 2	Name2 RNA binding motif protein 43	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CBS and SMARCAD1	Name 1 cystathionine beta-synthase	Name2 SNF2 related chromatin remodeling ATPase with DExD box 1	Pathway 1 Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Pathway 2	Drugs 1 Pyridoxal phosphate Ademetionine Serine Cysteine	Drugs 2	Diseases 1 Homocystinuria	Diseases 2
Novel	Symbols TRIP13 and TNRC6A	Name 1 thyroid hormone receptor interactor 13	Name2 trinucleotide repeat containing adaptor 6A	Pathway 1	Pathway 2 Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MDFI and TNP2	Name 1 MyoD family inhibitor	Name2 transition protein 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RBPMS and NYNRIN	Name 1 RNA binding protein, mRNA processing factor	Name2 NYN domain and retroviral integrase containing	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RBPMS and CPEB2	Name 1 RNA binding protein, mRNA processing factor	Name2 cytoplasmic polyadenylation element binding protein 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NEK6 and EML4	Name 1 NIMA related kinase 6	Name2 EMAP like 4	Pathway 1 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Pathway 2 EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Non-small cell lung cancer
Novel	Symbols YWHAG and SRGAP2	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Name2 SLIT-ROBO Rho GTPase activating protein 2	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Pathway 2 Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols YWHAG and TBC1D4	Name 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Name2 TBC1 domain family member 4	Pathway 1 Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Pathway 2 Translocation of SLC2A4 (GLUT4) to the plasma membrane	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols OTX1 and KCNK16	Name 1 orthodenticle homeobox 1	Name2 potassium two pore domain channel subfamily K member 16	Pathway 1	Pathway 2 TWIK-related alkaline pH activated K+ channel (TALK) Phase 4 - resting membrane potential	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FXR2 and KCNRG	Name 1 FMR1 autosomal homolog 2	Name2 potassium channel regulator	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ANXA11 and PLSCR1	Name 1 annexin A11	Name2 phospholipid scramblase 1	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP1M1 and LRMDA	Name 1 adaptor related protein complex 1 subunit mu 1	Name2 leucine rich melanocyte differentiation associated	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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