EXOSC8 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
NTAQ1	N-terminal glutamine amidase 1
NXF1	nuclear RNA export factor 1	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
OTUD4	OTU deubiquitinase 4
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	Clathrin-mediated endocytosis
PALS2	protein associated with LIN7 2, MAGUK p55 family member
PHF21A	PHD finger protein 21A	HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
PIAS2	protein inhibitor of activated STAT 2	Activation of anterior HOX genes in hindbrain development during early embryogenesis
PKP2	plakophilin 2	Keratinization Formation of the cornified envelope	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
POLDIP3	DNA polymerase delta interacting protein 3	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
PRC1	protein regulator of cytokinesis 1	RHO GTPases activate CIT
PRPF31	pre-mRNA processing factor 31	mRNA Splicing - Major Pathway	Retinitis pigmentosa (RP)
PRPF6	pre-mRNA processing factor 6	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
PRR3	proline rich 3
RASD1	ras related dexamethasone induced 1
RASSF1	Ras association domain family member 1		Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
RBBP4	RB binding protein 4, chromatin remodeling factor	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
RBM22	RNA binding motif protein 22	mRNA Splicing - Major Pathway
RBM7	RNA binding motif protein 7	mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
REL	REL proto-oncogene, NF-kB subunit	Activation of NF-kappaB in B cells	Hodgkin lymphoma
RFC5	replication factor C subunit 5	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51

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