Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols PRKAB2 and ZNF236	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 zinc finger protein 236	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDC5L and MACF1	Name 1 cell division cycle 5 like	Name2 microtubule actin crosslinking factor 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TRIP6 and NUP210	Name 1 thyroid hormone receptor interactor 6	Name2 nucleoporin 210	Pathway 1	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TLR4 and NOX4	Name 1 toll like receptor 4	Name2 NADPH oxidase 4	Pathway 1 ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Pathway 2 Detoxification of Reactive Oxygen Species STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	Drugs 1 Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Diseases 2
Novel Novel	Symbols SMAD3 and SVEP1	Name 1 SMAD family member 3	Name2 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MVD and BTAF1	Name 1 mevalonate diphosphate decarboxylase	Name2 B-TFIID TATA-box binding protein associated factor 1	Pathway 1 Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Synthesis of dolichyl-phosphate	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols VAMP4 and PTGES	Name 1 vesicle associated membrane protein 4	Name2 prostaglandin E synthase	Pathway 1 Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Pathway 2 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols UBE2L3 and HECTD4	Name 1 ubiquitin conjugating enzyme E2 L3	Name2 HECT domain E3 ubiquitin protein ligase 4	Pathway 1 PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CUL2 and ARID1B	Name 1 cullin 2	Name2 AT-rich interaction domain 1B	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2 RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HGS and MTHFD1L	Name 1 hepatocyte growth factor-regulated tyrosine kinase substrate	Name2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Pathway 1 EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Pathway 2 Metabolism of folate and pterines	Drugs 1 Citric acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HGS and SNX7	Name 1 hepatocyte growth factor-regulated tyrosine kinase substrate	Name2 sorting nexin 7	Pathway 1 EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Pathway 2	Drugs 1 Citric acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GADD45G and ZNF664	Name 1 growth arrest and DNA damage inducible gamma	Name2 zinc finger protein 664	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NBL1 and MRPL12	Name 1 NBL1, DAN family BMP antagonist	Name2 mitochondrial ribosomal protein L12	Pathway 1	Pathway 2 Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols P4HB and KLHL42	Name 1 prolyl 4-hydroxylase subunit beta	Name2 kelch like family member 42	Pathway 1 Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Pathway 2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TARBP2 and ZNF346	Name 1 TARBP2 subunit of RISC loading complex	Name2 zinc finger protein 346	Pathway 1 MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CNKSR1 and SASH1	Name 1 connector enhancer of kinase suppressor of Ras 1	Name2 SAM and SH3 domain containing 1	Pathway 1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols HDAC2 and TMEM132D	Name 1 histone deacetylase 2	Name2 transmembrane protein 132D	Pathway 1 p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Pathway 2	Drugs 1 Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ASIC3 and PATJ	Name 1 acid sensing ion channel subunit 3	Name2 PATJ crumbs cell polarity complex component	Pathway 1 Stimuli-sensing channels	Pathway 2 Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Drugs 1 Agmatine	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PAX6 and BCL2L15	Name 1 paired box 6	Name2 BCL2 like 15	Pathway 1 Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Diseases 2
Novel Novel	Symbols PAX6 and SLC12A8	Name 1 paired box 6	Name2 solute carrier family 12 member 8	Pathway 1 Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Diseases 2
Novel	Symbols PRKAB2 and ZNF236	Name 1 protein kinase AMP-activated non-catalytic subunit beta 2	Name2 zinc finger protein 236	Pathway 1 Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Pathway 2	Drugs 1 Adenosine phosphate Acetylsalicylic acid Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDC5L and MACF1	Name 1 cell division cycle 5 like	Name2 microtubule actin crosslinking factor 1	Pathway 1 mRNA Splicing - Major Pathway	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TRIP6 and NUP210	Name 1 thyroid hormone receptor interactor 6	Name2 nucleoporin 210	Pathway 1	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TLR4 and NOX4	Name 1 toll like receptor 4	Name2 NADPH oxidase 4	Pathway 1 ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions	Pathway 2 Detoxification of Reactive Oxygen Species STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	Drugs 1 Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide	Drugs 2	Diseases 1 Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Diseases 2
Novel	Symbols SMAD3 and SVEP1	Name 1 SMAD family member 3	Name2 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	Pathway 1 Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MVD and BTAF1	Name 1 mevalonate diphosphate decarboxylase	Name2 B-TFIID TATA-box binding protein associated factor 1	Pathway 1 Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Synthesis of dolichyl-phosphate	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols VAMP4 and PTGES	Name 1 vesicle associated membrane protein 4	Name2 prostaglandin E synthase	Pathway 1 Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Pathway 2 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols UBE2L3 and HECTD4	Name 1 ubiquitin conjugating enzyme E2 L3	Name2 HECT domain E3 ubiquitin protein ligase 4	Pathway 1 PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CUL2 and ARID1B	Name 1 cullin 2	Name2 AT-rich interaction domain 1B	Pathway 1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Pathway 2 RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HGS and MTHFD1L	Name 1 hepatocyte growth factor-regulated tyrosine kinase substrate	Name2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Pathway 1 EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Pathway 2 Metabolism of folate and pterines	Drugs 1 Citric acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HGS and SNX7	Name 1 hepatocyte growth factor-regulated tyrosine kinase substrate	Name2 sorting nexin 7	Pathway 1 EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Pathway 2	Drugs 1 Citric acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GADD45G and ZNF664	Name 1 growth arrest and DNA damage inducible gamma	Name2 zinc finger protein 664	Pathway 1	Pathway 2 Generic Transcription Pathway	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NBL1 and MRPL12	Name 1 NBL1, DAN family BMP antagonist	Name2 mitochondrial ribosomal protein L12	Pathway 1	Pathway 2 Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols P4HB and KLHL42	Name 1 prolyl 4-hydroxylase subunit beta	Name2 kelch like family member 42	Pathway 1 Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Pathway 2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TARBP2 and ZNF346	Name 1 TARBP2 subunit of RISC loading complex	Name2 zinc finger protein 346	Pathway 1 MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CNKSR1 and SASH1	Name 1 connector enhancer of kinase suppressor of Ras 1	Name2 SAM and SH3 domain containing 1	Pathway 1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HDAC2 and TMEM132D	Name 1 histone deacetylase 2	Name2 transmembrane protein 132D	Pathway 1 p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Pathway 2	Drugs 1 Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ASIC3 and PATJ	Name 1 acid sensing ion channel subunit 3	Name2 PATJ crumbs cell polarity complex component	Pathway 1 Stimuli-sensing channels	Pathway 2 Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Drugs 1 Agmatine	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PAX6 and BCL2L15	Name 1 paired box 6	Name2 BCL2 like 15	Pathway 1 Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Diseases 2
Novel	Symbols PAX6 and SLC12A8	Name 1 paired box 6	Name2 solute carrier family 12 member 8	Pathway 1 Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Diseases 2

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