Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols DLG3 and NLGN1	Name 1 discs large MAGUK scaffold protein 3	Name2 neuroligin 1	Pathway 1 Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel Novel	Symbols MAGED1 and LARP4B	Name 1 MAGE family member D1	Name2 La ribonucleoprotein 4B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MAGED1 and DMRT2	Name 1 MAGE family member D1	Name2 doublesex and mab-3 related transcription factor 2	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols UBE3A and SACS	Name 1 ubiquitin protein ligase E3A	Name2 sacsin molecular chaperone	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Diseases 2
Novel Novel	Symbols UBE3A and ASAP3	Name 1 ubiquitin protein ligase E3A	Name2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Diseases 2
Novel Novel	Symbols CTBP2 and NOL4	Name 1 C-terminal binding protein 2	Name2 nucleolar protein 4	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CTBP2 and KLF3	Name 1 C-terminal binding protein 2	Name2 KLF transcription factor 3	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CTBP2 and IKZF2	Name 1 C-terminal binding protein 2	Name2 IKAROS family zinc finger 2	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CTBP2 and DTNB	Name 1 C-terminal binding protein 2	Name2 dystrobrevin beta	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CTBP2 and LCORL	Name 1 C-terminal binding protein 2	Name2 ligand dependent nuclear receptor corepressor like	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCRS1 and JAKMIP1	Name 1 microspherule protein 1	Name2 janus kinase and microtubule interacting protein 1	Pathway 1 HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCRS1 and BEND3	Name 1 microspherule protein 1	Name2 BEN domain containing 3	Pathway 1 HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols XPO1 and KIF17	Name 1 exportin 1	Name2 kinesin family member 17	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Intraflagellar transport Assembly and cell surface presentation of NMDA receptors	Drugs 1 Selinexor	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols DMD and DTNA	Name 1 dystrophin	Name2 dystrobrevin alpha	Pathway 1 Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Golodirsen	Drugs 2	Diseases 1 Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)	Diseases 2
Novel Novel	Symbols DMD and SGCZ	Name 1 dystrophin	Name2 sarcoglycan zeta	Pathway 1 Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Golodirsen	Drugs 2	Diseases 1 Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)	Diseases 2
Novel Novel	Symbols GATA1 and ZZZ3	Name 1 GATA binding protein 1	Name2 zinc finger ZZ-type containing 3	Pathway 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production	Pathway 2 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Drugs 1	Drugs 2	Diseases 1 Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Diseases 2
Novel Novel	Symbols FMR1 and DGKD	Name 1 fragile X messenger ribonucleoprotein 1	Name2 diacylglycerol kinase delta	Pathway 1	Pathway 2 Effects of PIP2 hydrolysis	Drugs 1	Drugs 2 Phosphatidyl serine alpha-Tocopherol succinate	Diseases 1 Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)	Diseases 2
Novel Novel	Symbols ARAF and CPS1	Name 1 A-Raf proto-oncogene, serine/threonine kinase	Name2 carbamoyl-phosphate synthase 1	Pathway 1 RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Pathway 2 Urea cycle	Drugs 1 ATP	Drugs 2 Carglumic acid	Diseases 1 Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Diseases 2 Carbamoyl phosphate synthetase I deficiency
Novel Novel	Symbols POLA1 and RBMS1	Name 1 DNA polymerase alpha 1, catalytic subunit	Name2 RNA binding motif single stranded interacting protein 1	Pathway 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis	Pathway 2	Drugs 1 Cladribine Clofarabine Fludarabine Nelarabine	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP1G1 and DNER	Name 1 adaptor related protein complex 1 subunit gamma 1	Name2 delta/notch like EGF repeat containing	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DLG3 and NLGN1	Name 1 discs large MAGUK scaffold protein 3	Name2 neuroligin 1	Pathway 1 Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Pathway 2 Neurexins and neuroligins Neurexins and neuroligins	Drugs 1	Drugs 2	Diseases 1 Non-syndromic X-linked mental retardation	Diseases 2
Novel	Symbols MAGED1 and LARP4B	Name 1 MAGE family member D1	Name2 La ribonucleoprotein 4B	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MAGED1 and DMRT2	Name 1 MAGE family member D1	Name2 doublesex and mab-3 related transcription factor 2	Pathway 1 NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols UBE3A and SACS	Name 1 ubiquitin protein ligase E3A	Name2 sacsin molecular chaperone	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Diseases 2
Novel	Symbols UBE3A and ASAP3	Name 1 ubiquitin protein ligase E3A	Name2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2	Drugs 1	Drugs 2	Diseases 1 Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Diseases 2
Novel	Symbols CTBP2 and NOL4	Name 1 C-terminal binding protein 2	Name2 nucleolar protein 4	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTBP2 and KLF3	Name 1 C-terminal binding protein 2	Name2 KLF transcription factor 3	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTBP2 and IKZF2	Name 1 C-terminal binding protein 2	Name2 IKAROS family zinc finger 2	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTBP2 and DTNB	Name 1 C-terminal binding protein 2	Name2 dystrobrevin beta	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CTBP2 and LCORL	Name 1 C-terminal binding protein 2	Name2 ligand dependent nuclear receptor corepressor like	Pathway 1 Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCRS1 and JAKMIP1	Name 1 microspherule protein 1	Name2 janus kinase and microtubule interacting protein 1	Pathway 1 HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCRS1 and BEND3	Name 1 microspherule protein 1	Name2 BEN domain containing 3	Pathway 1 HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols XPO1 and KIF17	Name 1 exportin 1	Name2 kinesin family member 17	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Intraflagellar transport Assembly and cell surface presentation of NMDA receptors	Drugs 1 Selinexor	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DMD and DTNA	Name 1 dystrophin	Name2 dystrobrevin alpha	Pathway 1 Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Golodirsen	Drugs 2	Diseases 1 Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)	Diseases 2
Novel	Symbols DMD and SGCZ	Name 1 dystrophin	Name2 sarcoglycan zeta	Pathway 1 Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Drugs 1 Golodirsen	Drugs 2	Diseases 1 Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)	Diseases 2
Novel	Symbols GATA1 and ZZZ3	Name 1 GATA binding protein 1	Name2 zinc finger ZZ-type containing 3	Pathway 1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production	Pathway 2 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Drugs 1	Drugs 2	Diseases 1 Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Diseases 2
Novel	Symbols FMR1 and DGKD	Name 1 fragile X messenger ribonucleoprotein 1	Name2 diacylglycerol kinase delta	Pathway 1	Pathway 2 Effects of PIP2 hydrolysis	Drugs 1	Drugs 2 Phosphatidyl serine alpha-Tocopherol succinate	Diseases 1 Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)	Diseases 2
Novel	Symbols ARAF and CPS1	Name 1 A-Raf proto-oncogene, serine/threonine kinase	Name2 carbamoyl-phosphate synthase 1	Pathway 1 RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Pathway 2 Urea cycle	Drugs 1 ATP	Drugs 2 Carglumic acid	Diseases 1 Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Diseases 2 Carbamoyl phosphate synthetase I deficiency
Novel	Symbols POLA1 and RBMS1	Name 1 DNA polymerase alpha 1, catalytic subunit	Name2 RNA binding motif single stranded interacting protein 1	Pathway 1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis	Pathway 2	Drugs 1 Cladribine Clofarabine Fludarabine Nelarabine	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP1G1 and DNER	Name 1 adaptor related protein complex 1 subunit gamma 1	Name2 delta/notch like EGF repeat containing	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 Activated NOTCH1 Transmits Signal to the Nucleus	Drugs 1	Drugs 2	Diseases 1	Diseases 2

Page 33 out of 58 pages

Search Results : Diabetes