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KRT39
|
keratin 39 |
- Keratinization
- Formation of the cornified envelope
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KRT40
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keratin 40 |
- Keratinization
- Formation of the cornified envelope
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LCN2
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lipocalin 2 |
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
- Metal sequestration by antimicrobial proteins
- Iron uptake and transport
- Iron uptake and transport
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- Methyl nonanoate
- 2,3-Dihydroxy-Benzoic Acid
- Carboxymycobactin S
- 2,3,-Dihydroxybenzoylserine
- Carboxymycobactin T
- Trencam-3,2-Hopo
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LNX1
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ligand of numb-protein X 1 |
- Antigen processing: Ubiquitination & Proteasome degradation
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LZTS1
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leucine zipper tumor suppressor 1 |
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LZTS2
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leucine zipper tumor suppressor 2 |
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MAP3K7
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mitogen-activated protein kinase kinase kinase 7 |
- Activation of NF-kappaB in B cells
- NOD1/2 Signaling Pathway
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- Ca2+ pathway
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- TNFR1-induced NF-kappa-B signaling pathway
- CLEC7A (Dectin-1) signaling
- Ub-specific processing proteases
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Interleukin-1 signaling
- IRAK2 mediated activation of TAK1 complex
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- Alpha-protein kinase 1 signaling pathway
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
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MKRN1
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makorin ring finger protein 1 |
- AKT phosphorylates targets in the cytosol
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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MTIF2
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mitochondrial translational initiation factor 2 |
- Mitochondrial translation initiation
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N4BP3
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NEDD4 binding protein 3 |
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NEUROD2
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neuronal differentiation 2 |
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NSMF
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NMDA receptor synaptonuclear signaling and neuronal migration factor |
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- Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
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PDE7A
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phosphodiesterase 7A |
- G alpha (s) signalling events
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- Caffeine
- 3-isobutyl-1-methyl-7H-xanthine
- 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one
- Trapidil
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PFDN2
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prefoldin subunit 2 |
- Prefoldin mediated transfer of substrate to CCT/TriC
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PLEKHB2
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pleckstrin homology domain containing B2 |
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PMEPA1
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prostate transmembrane protein, androgen induced 1 |
- Downregulation of TGF-beta receptor signaling
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PNMA5
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PNMA family member 5 |
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PRDM6
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PR/SET domain 6 |
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PRKN
|
parkin RBR E3 ubiquitin protein ligase |
- PINK1-PRKN Mediated Mitophagy
- Regulation of necroptotic cell death
- Josephin domain DUBs
- Aggrephagy
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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PSMC1
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proteasome 26S subunit, ATPase 1 |
- Activation of NF-kappaB in B cells
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- ER-Phagosome pathway
- Cross-presentation of soluble exogenous antigens (endosomes)
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- Downstream TCR signaling
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Separation of Sister Chromatids
- FCERI mediated NF-kB activation
- Autodegradation of the E3 ubiquitin ligase COP1
- Regulation of ornithine decarboxylase (ODC)
- ABC-family proteins mediated transport
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAPK6/MAPK4 signaling
- UCH proteinases
- Ub-specific processing proteases
- Assembly of the pre-replicative complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- G2/M Checkpoints
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN stability and activity
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Interleukin-1 signaling
- Negative regulation of NOTCH4 signaling
- KEAP1-NFE2L2 pathway
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- Degradation of CDH1
- Somitogenesis
- Antigen processing: Ubiquitination & Proteasome degradation
- Proteasome assembly
- Proteasome assembly
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
- AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
- Degradation of CRY and PER proteins
- Degradation of CRY and PER proteins
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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