TLE1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HHEX	hematopoietically expressed homeobox	Developmental Lineage of Multipotent Pancreatic Progenitor Cells		Type II diabetes mellitus
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling		Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Dilated cardiomyopathy (DCM) Type I diabetes mellitus
HMGB1	high mobility group box 1	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Chloroquine Ethyl pyruvate
HNF1A	HNF1 homeobox A	Regulation of gene expression in beta cells	D-norleucine	Maturity onset diabetes of the young (MODY)
HSPE1	heat shock protein family E (Hsp10) member 1	RHOG GTPase cycle Mitochondrial unfolded protein response (UPRmt)	Phenethyl Isothiocyanate
IL6ST	interleukin 6 cytokine family signal transducer	Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
KDM6A	lysine demethylase 6A	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
KIAA0408	KIAA0408
LEF1	lymphoid enhancer binding factor 1	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Cardiogenesis Germ layer formation at gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription	Etacrynic acid
MORF4L2	mortality factor 4 like 2	HATs acetylate histones
MPHOSPH6	M-phase phosphoprotein 6	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
MSX1	msh homeobox 1	Specification of the neural plate border		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth and nail syndrome; Witkop syndrome Tooth agenesis; Hypodontia
MSX2	msh homeobox 2	Regulation of RUNX2 expression and activity		Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
NKX2-5	NK2 homeobox 5	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis		Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
NUDT21	nudix hydrolase 21	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
PAFAH1B3	platelet activating factor acetylhydrolase 1b catalytic subunit 3	COPI-independent Golgi-to-ER retrograde traffic	(1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
PAX9	paired box 9			Tooth agenesis; Hypodontia
PCDHA4	protocadherin alpha 4
PEX2	peroxisomal biogenesis factor 2	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
PFN1	profilin 1	Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol

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