STOM - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HMOX2	heme oxygenase 2	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1	NADH Stannsoporfin
KCNK1	potassium two pore domain channel subfamily K member 1	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	Ibutilide Quinidine Quinidine barbiturate
KTN1	kinectin 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
LANCL1	LanC like glutathione S-transferase 1
LNPEP	leucyl and cystinyl aminopeptidase	Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation
MGLL	monoglyceride lipase	Acyl chain remodeling of DAG and TAG Triglyceride catabolism Arachidonate production from DAG MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MMP14	matrix metallopeptidase 14	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Marimastat
NKG7	natural killer cell granule protein 7
ORMDL1	ORMDL sphingolipid biosynthesis regulator 1	Sphingolipid de novo biosynthesis
PEDS1-UBE2V1	PEDS1-UBE2V1 readthrough
PEMT	phosphatidylethanolamine N-methyltransferase	Synthesis of PC
PGA4	pepsinogen A4	Surfactant metabolism
PMP22	peripheral myelin protein 22	EGR2 and SOX10-mediated initiation of Schwann cell myelination		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
PTCH1	patched 1	Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO		Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
RPL13A	ribosomal protein L13a	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	(S)-3-phenyllactic acid Anisomycin Puromycin
RPRM	reprimo, TP53 dependent G2 arrest mediator homolog
RTP2	receptor transporter protein 2	Expression and translocation of olfactory receptors
RUVBL1	RuvB like AAA ATPase 1	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
RUVBL2	RuvB like AAA ATPase 2	Telomere Extension By Telomerase HATs acetylate histones	Quercetin
SCD	stearoyl-CoA desaturase	Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis

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