Search Results for: PSEN1

98 interactions involving PSEN1 - presenilin 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ETFA electron transfer flavoprotein subunit alpha
  • Respiratory electron transport
  • Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
FBXL12 F-box and leucine rich repeat protein 12
  • Neddylation
  • Antigen processing: Ubiquitination & Proteasome degradation
FBXW7 F-box and WD repeat domain containing 7
  • Association of TriC/CCT with target proteins during biosynthesis
  • Neddylation
  • Antigen processing: Ubiquitination & Proteasome degradation
FGF13 fibroblast growth factor 13
  • Phase 0 - rapid depolarisation
FLNA filamin A
  • Platelet degranulation
  • GP1b-IX-V activation signalling
  • Cell-extracellular matrix interactions
  • RHO GTPases activate PAKs
  • OAS antiviral response
  • Artenimol
  • FG syndrome (FGS); Opitz-Kaveggia syndrome
  • Periventricular nodular heterotopia (PVNH)
  • Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
  • Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
FLNB filamin B
  • ISG15 antiviral mechanism
  • FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
  • Spondylocarpotarsal synostosis syndrome
GAPDH glyceraldehyde-3-phosphate dehydrogenase
  • Glycolysis
  • Gluconeogenesis
  • NADH
  • Adenosine-5-Diphosphoribose
  • Thionicotinamide-Adenine-Dinucleotide
  • 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
  • Xanthinol
  • Copper
  • Artenimol
GCDH glutaryl-CoA dehydrogenase
  • Lysine catabolism
  • Flavin adenine dinucleotide
  • S-4-Nitrobutyryl-CoA
  • Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GDI1 GDP dissociation inhibitor 1
  • RAB GEFs exchange GTP for GDP on RABs
  • Non-syndromic X-linked mental retardation
GFAP glial fibrillary acidic protein
  • Nuclear signaling by ERBB4
  • Chaperone Mediated Autophagy
  • Alexander disease
GSK3B glycogen synthase kinase 3 beta
  • Degradation of beta-catenin by the destruction complex
  • Beta-catenin phosphorylation cascade
  • AKT phosphorylates targets in the cytosol
  • Regulation of HSF1-mediated heat shock response
  • CRMPs in Sema3A signaling
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • B-WICH complex positively regulates rRNA expression
  • Signaling by GSK3beta mutants
  • CTNNB1 S33 mutants aren't phosphorylated
  • CTNNB1 S37 mutants aren't phosphorylated
  • CTNNB1 S45 mutants aren't phosphorylated
  • CTNNB1 T41 mutants aren't phosphorylated
  • APC truncation mutants have impaired AXIN binding
  • AXIN missense mutants destabilize the destruction complex
  • Truncations of AMER1 destabilize the destruction complex
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • Regulation of RUNX2 expression and activity
  • Maturation of nucleoprotein
  • Maturation of nucleoprotein
  • GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
  • Transcriptional and post-translational regulation of MITF-M expression and activity
  • GSK3B-mediated proteasomal degradation of PD-L1(CD274)
  • Lithium cation
  • 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
  • SB-409513
  • AR-AO-14418
  • Staurosporine
  • Indirubin-3'-monoxime
  • 6-bromoindirubin-3'-oxime
  • Alsterpaullone
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
  • 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
  • (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
  • N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
  • 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
  • N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
  • 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
  • ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
  • (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
  • Fostamatinib
  • Tideglusib
  • Lithium citrate
  • Lithium succinate
  • Lithium carbonate
HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1
  • ATF4 activates genes in response to endoplasmic reticulum stress
HMGB1 high mobility group box 1
  • ER-Phagosome pathway
  • Apoptosis induced DNA fragmentation
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • TAK1-dependent IKK and NF-kappa-B activation
  • MyD88 deficiency (TLR2/4)
  • IRAK4 deficiency (TLR2/4)
  • Pyroptosis
  • Regulation of TLR by endogenous ligand
  • Neutrophil degranulation
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • TRAF6 mediated NF-kB activation
  • Chloroquine
  • Ethyl pyruvate
ICAM5 intercellular adhesion molecule 5
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • Integrin cell surface interactions
ITSN2 intersectin 2
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • RHOU GTPase cycle
JUP junction plakoglobin
  • Adherens junctions interactions
  • VEGFR2 mediated vascular permeability
  • Neutrophil degranulation
  • Keratinization
  • Formation of the cornified envelope
  • RHOA GTPase cycle
  • RHOB GTPase cycle
  • RHOC GTPase cycle
  • CDC42 GTPase cycle
  • RHOQ GTPase cycle
  • RHOH GTPase cycle
  • RHOJ GTPase cycle
  • Regulation of CDH11 function
  • Regulation of CDH11 function
  • Regulation of CDH19 Expression and Function
  • Regulation of CDH1 Function
  • Degradation of CDH1
  • Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
  • CDH11 homotypic and heterotypic interactions
  • Zinc
  • Zinc acetate
  • Naxos disease and Carvajal syndrome
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KANK2 KN motif and ankyrin repeat domains 2
KCNIP3 potassium voltage-gated channel interacting protein 3
  • Phase 1 - inactivation of fast Na+ channels
  • Regulation of NPAS4 gene transcription
KCNIP4 potassium voltage-gated channel interacting protein 4
  • Phase 1 - inactivation of fast Na+ channels
MAPK9 mitogen-activated protein kinase 9
  • Oxidative Stress Induced Senescence
  • FCERI mediated MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • Activation of the AP-1 family of transcription factors
  • Signaling by ALK fusions and activated point mutants
  • Minocycline
  • N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
  • Fostamatinib
  • Halicin

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